The acute or chronic drug treatments for different neurodegenerative and psychiatric
disorders are challenging from several aspects. The low bioavailability and limited brain …

Purpose To summarize definitions, prevalence, risk factors, consequences, and acute
management of seizure clusters using rescue medications. Methods We searched MEDLINE …

Epileptic seizures and anxiety crisis are severe conditions that require fast and effective
treatment, targeting the brain. Current emergency antiepiletics and anxiolytics have limited …

Epileptic seizure emergencies are life-threatening conditions, which in their most severe
form, status epilepticus, have a high mortality rate if not quickly terminated. Treatment …

Abstract Lower Urinary Tract Symptoms (LUTS) are frequently present in the general
population as patients age with approximately a third of individuals experiencing LUTS …

Objective To evaluate the safety and efficacy of a novel formulation of midazolam
administered as a single‐dose nasal spray (MDZ–NS) in the outpatient treatment of patients …

Dravet syndrome is a debilitating epileptic encephalopathy of childhood with few treatment
options available in the United States before 2018. In the modern era, new genetic testing …

Objective The study assesses the bioavailability of diazepam after intranasal administration
(diazepam nasal spray) in healthy volunteers. Comparative agents were diazepam rectal …

Objective To evaluate safety‐and seizure‐related outcomes with repeated intermittent use of
a novel formulation of midazolam administered as a single‐dose nasal spray (MDZ‐NS) in …

The intranasal route for medication administration is increasingly popular in the emergency
department and out-of-hospital setting because such administration is simple and fast, and …