Cryptococcus neoformans and Cryptococcus gattii are the two etiologic agents of
cryptococcosis. They belong to the phylum Basidiomycota and can be readily distinguished …

Mucormycosis is a life-threatening infection that occurs in patients who are
immunocompromised because of diabetic ketoacidosis, neutropenia, organ transplantation …

Metals are essential for life, and they play a central role in the struggle between infecting
microbes and their hosts. In fact, an important aspect of microbial pathogenesis is the …

Iron is the most abundant transition metal in the human body and its bioavailability is
stringently controlled. In particular, iron is tightly bound to host proteins such as transferrin to …

The human fungal pathogen Cryptococcus neoformans is characterized by its ability to
induce a distinct polysaccharide capsule in response to a number of host-specific …

The fungus Cryptococcus neoformans is a leading cause of mortality and morbidity among
HIV-infected individuals. We utilized the completed genome sequence and optimized …

Iron sequestration by host iron-binding proteins is an important mechanism of resistance to
microbial infections. Inside oral epithelial cells, iron is stored within ferritin, and is therefore …

Whereas extracellular vesicle (EV) research has become commonplace in different
biomedical fields, this field of research is still in its infancy in mycology. Here we provide a …

Copper (Cu) is an essential metal that is toxic at high concentrations. Thus, pathogens often
rely on host Cu for growth, but host cells can hyperaccumulate Cu to exert antimicrobial …

Iron is an essential but, in excess, toxic nutrient. Therefore, fungi evolved fine-tuned
mechanisms for uptake and storage of iron, such as the production of siderophores (low …