Epigenetic mechanisms control gene activity and the development of an organism. The
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …

Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and is
associated with a substantially increased lifetime risk of comorbidities, including type 2 …

Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait …

Obesity increases the risks of developing cardiovascular and metabolic diseases and
degrades quality of life, ultimately increasing the risk of death. However, not all forms of …

While obesity and associated metabolic complications are linked to inflammation of white
adipose tissue (WAT), the causal factors remain unclear. We hypothesized that the local …

Nowadays, obesity is one of the largest public health problems worldwide. In the last few
decades, there has been a marked increase in the obesity epidemic and its related …

Epigenetic changes are caused by biochemical regulators of gene expression that can be
transferred across generations or through cell division. Epigenetic modifications can arise …

Objective Precision medicine utilizes genomic and other data to optimize and personalize
treatment. Although more than 2,500 genetic tests are currently available, largely for extreme …

Modern lifestyle, genetics, nutritional overload through high-fat diet attributed prevalence
and diabetes outcomes with various complications primarily due to obesity in which energy …

Environmental factors (eg, malnutrition and physical inactivity) contribute largely to
metabolic disorders including obesity, type 2 diabetes, cardiometabolic disease and …