Abdominal aortic aneurysm: roles of inflammatory cells

Z Yuan, Y Lu, J Wei, J Wu, J Yang, Z Cai - Frontiers in immunology, 2021 - frontiersin.org
Abdominal aortic aneurysms (AAAs) are local dilations of infrarenal segment of aortas.
Molecular mechanisms underlying the pathogenesis of AAA remain not fully clear. However …

Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm

S Jana, M Hu, M Shen, Z Kassiri - Experimental & molecular medicine, 2019 - nature.com
Aortic aneurysm is an asymptomatic disease with dire outcomes if undiagnosed. Aortic
aneurysm rupture is a significant cause of death worldwide. To date, surgical repair or …

2022 ACC/AHA guideline for the diagnosis and management of aortic disease: a report of the American Heart Association/American College of Cardiology Joint …

Writing Committee Members, EM Isselbacher… - Journal of the American …, 2022 - jacc.org
Abstract Aim The “2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic
Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation …

[HTML][HTML] Cathepsin S (CTSS) activity in health and disease-A treasure trove of untapped clinical potential

P Smyth, J Sasiwachirangkul, R Williams… - Molecular aspects of …, 2022 - Elsevier
Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …

Exosomal miR-17-5p from adipose-derived mesenchymal stem cells inhibits abdominal aortic aneurysm by suppressing TXNIP-NLRP3 inflammasome

J Hu, Y Jiang, X Wu, Z Wu, J Qin, Z Zhao, B Li… - Stem Cell Research & …, 2022 - Springer
Background Preclinical studies have suggested that adipose-derived mesenchymal stem
cells (ADSCs) transplantation can suppress abdominal aortic inflammation and aneurysm …

Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm

R Gurung, AM Choong, CC Woo, R Foo… - International journal of …, 2020 - mdpi.com
Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …

MicroRNA-34a: the bad guy in age-related vascular diseases

A Raucci, F Macrì, S Castiglione, I Badi… - Cellular and Molecular …, 2021 - Springer
The age-related vasculature alteration is the prominent risk factor for vascular diseases
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on …

J van der Velden, FW Asselbergs… - Cardiovascular …, 2022 - academic.oup.com
Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation

AC Filiberto, MD Spinosa, CT Elder, G Su… - Nature …, 2022 - nature.com
Abstract Pannexin-1 (Panx1) channels have been shown to regulate leukocyte trafficking
and tissue inflammation but the mechanism of Panx1 in chronic vascular diseases like …

Smoking and the pathophysiology of peripheral artery disease

W Wang, T Zhao, K Geng, G Yuan, Y Chen… - Frontiers in …, 2021 - frontiersin.org
Smoking is one of the most important preventable factors causing peripheral artery disease
(PAD). The purpose of this review is to comprehensively analyze and summarize the …