Abstract “De novo” genes evolve from previously non-genic DNA. This strikes many of us as
remarkable, because it seems extraordinarily unlikely that random sequence would produce …

Pancreatic ductal metaplasia (PDM) is the transformation of potentially many type of cells in
pancreas into ductal or ductal-like cells, which eventually replace the existing differentiated …

Pancreatic adenocarcinoma (PAAD) is a deadly digestive system tumor with a poor
prognosis. Recently, necroptosis has been considered as a type of inflammatory …

Background Pancreatic adenocarcinoma (PAAD) is one of the most challenging cancers
with high morbidity and mortality. KRAS mutations could occur as an early event in PAAD …

Cancer-associated fibroblasts (CAFs) are increasingly recognized as playing a crucial role
in regulating cancer progression and metastasis. These cells can be activated by long non …

Objective: Necroptosis represents a new target for cancer immunotherapy and is considered
a form of cell death that overcomes apoptosis resistance and enhances tumor …

Background While molecular targeted drugs and other therapies are being developed for
many tumors, pancreatic cancer is still considered to be the malignant tumor with the worst …

Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer. Approximately
80% of patients initially diagnosed with locally advanced or metastatic disease survive only …

Purpose: Considerable variations in methylation profile have been found in various cancers
to modulate tumorigenesis and affect prognosis. To provide a theoretical basis for early …

Childhood socioeconomic position (SEP) is a major determinant of health and well-being
across the entire life course. To effectively prevent and reduce health risks related to SEP, it …