Only a fraction of oocytes present in the ovaries at birth are ever ovulated during the lifetime
of a female mammal. In vitro maturation (IVM) offers the possibility to exploit what is a largely …

DNA methylation is one of the main epigenetic phenomena affecting gene expression. It is
an important mechanism for the development of embryo, growth and health of animals. As a …

Pregnancy success results from the interaction of multiple factors, among them are
folliculogenesis and early embryonic development. Failure during these different processes …

Abstract STUDY QUESTION Does ICSI induce specific DNA methylation changes in the
resulting offspring? SUMMARY ANSWER Although several thousand analyzed CpG sites …

Simple Summary Artificial reproduction techniques (ART) are used widely in human
medicine to overcome infertility, with about one in seven couples being concerned in the …

Assisted reproductive techniques (ART) and parental nutritional status have profound effects
on embryonic/fetal and placental development, which are probably mediated via …

STUDY QUESTION Do primordial-primary versus secondary follicles embedded inside a
fibrin matrix have different capabilities to survive and grow after isolation and …

During the last 2 decades, research on in vitro preantral follicle growth and oocyte
maturation has delivered fascinating advances concerning the knowledge of processes …

Purpose DNA methylation is an epigenetic mechanism that plays critical roles during
mammalian oocyte and preimplantation embryo development. It is achieved by adding a …

It is well established that there is a heritable element of susceptibility to chronic human
ailments, yet there is compelling evidence that some components of such heritability are …