Metazoan promoters are enriched in secondary DNA structure-forming motifs, such as G-
quadruplexes (G4s). Here we describe 'G4access', an approach to isolate and sequence …

DNA methylation is prevalent in mammalian genomes and plays a central role in the
epigenetic control of development. The mammalian DNA methylation machinery is thought …

Background As the most stable and experimentally accessible epigenetic mark, DNA
methylation is of great interest to the research community. The landscape of DNA …

In mammals, most somatic cells contain two copies of each autosomal gene, one inherited
from each parent. When a gene is expressed, both parental alleles are usually transcribed …

The epigenetics community was an early adopter of next generation sequencing (NGS).
NGS-based studies have provided detailed and comprehensive views of epigenetic …

DNA methylation is extensively remodeled during mammalian gametogenesis and
embryogenesis. Most transposons become hypomethylated, raising the question of their …

Differential methylation of the two parental genomes in placental mammals is essential for
genomic imprinting and embryogenesis. To systematically study this epigenetic process, we …

Genomic imprinting results in preferential expression of the paternal or maternal allele of
certain genes. We have performed a genome-wide characterization of imprinting in the …

Genomic imprinting is an epigenetic process that restricts gene expression to either the
maternally or paternally inherited allele,. Many theories have been proposed to explain its …

In contrast to existing estimates of approximately 200 murine imprinted genes, recent work
based on transcriptome sequencing uncovered parent-of-origin allelic effects at more than …