Metastatic disease is the leading cause of death in patients with solid cancers. The
progression to metastasis is a multistep process that involves detachment of tumor cells from …

Secreted protein acidic and rich in cysteine (SPARC) is a matricellular, collagen-binding
protein. Matricellular proteins are described as extracellular matrix-associated proteins that …

The molecular circuitries controlling osseous prostate metastasis are known to depend on
the activity of multiple pathways, including integrin signaling. Here, we demonstrate that the …

Tumor microenvironment (TME) is a complex and constantly evolving entity that consists not
only of cancer cells, but also of resident host cells and immune-infiltrating cells, among …

Tissue inhibitor of metalloproteinases-1 (TIMP-1) exerts pleiotropic effects on cells including
conferring metastatic properties to cancer cells. As for metastatic cells, recent paradigms of …

The stroma in human carcinomas consists of extracellular matrix and various types of non-
carcinoma cells, mainly leukocytes, endothelial cells, fibroblasts, myofibroblasts and bone …

Simple Summary Giant cells (GCs) are found in many different tissues and among different
backgrounds, including reactive, and neoplastic settings. It is not yet fully understood …

The complex interaction between cells undergoing transformation and the various stromal
and immunological cell components of the tumor microenvironment (TME) crucially …

Background: Mechanics is increasingly being recognized as the fourth essential factor in
bone tissue engineering next to cell, scaffold, and growth factors. The development of …

Accumulating evidence suggests that iron homeostasis is disturbed in tumors. We aimed at
clarifying the distribution of iron in renal cell carcinoma (RCC). Considering the pivotal role …