Circadian rhythm disruption in cancer biology
C Savvidis, M Koutsilieris - Molecular medicine, 2012 - Springer
Circadian rhythms show universally a 24-h oscillation pattern in metabolic, physiological
and behavioral functions of almost all species. This pattern is due to a fundamental …
and behavioral functions of almost all species. This pattern is due to a fundamental …
Epigenetic targeting of histone deacetylase: therapeutic potential in Parkinson's disease?
IF Harrison, DT Dexter - Pharmacology & therapeutics, 2013 - Elsevier
Parkinson's disease (PD) is the most common movement disorder affecting more than 4
million people worldwide. The primary motor symptoms of the disease are due to …
million people worldwide. The primary motor symptoms of the disease are due to …
Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA
A Szwagierczak, S Bultmann, CS Schmidt… - Nucleic acids …, 2010 - academic.oup.com
The recent discovery of genomic 5-hydroxymethylcytosine (hmC) and mutations affecting the
respective Tet hydroxylases in leukemia raises fundamental questions about this epigenetic …
respective Tet hydroxylases in leukemia raises fundamental questions about this epigenetic …
Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance
Adiponectin plays a key role in the regulation of the whole-body energy homeostasis by
modulating glucose and lipid metabolism. Although obesity-induced reduction of …
modulating glucose and lipid metabolism. Although obesity-induced reduction of …
Epigenetics: molecular mechanisms and implications for disease
Epigenetics is rising to prominence in biology as a mechanism by which environmental
factors have intermediate-term effects on gene expression without changing the underlying …
factors have intermediate-term effects on gene expression without changing the underlying …
Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain
C Frauer, T Hoffmann, S Bultmann, V Casa… - PloS one, 2011 - journals.plos.org
Recent discovery of 5-hydroxymethylcytosine (5hmC) in genomic DNA raises the question
how this sixth base is recognized by cellular proteins. In contrast to the methyl-CpG binding …
how this sixth base is recognized by cellular proteins. In contrast to the methyl-CpG binding …
Determination of DNA and RNA methylation in circulating tumor cells by mass spectrometry
DNA methylation (5-methylcytosine, 5-mC) is the best characterized epigenetic mark that
has regulatory roles in diverse biological processes. Recent investigation of RNA …
has regulatory roles in diverse biological processes. Recent investigation of RNA …
In vitro culture: an epigenetic challenge for plants
R Us-Camas, G Rivera-Solís, F Duarte-Aké… - Plant Cell, Tissue and …, 2014 - Springer
In vitro plant cell and tissue culture techniques are the basis of many micropropagation and
breeding programs for scientific research. Plant tissue culture (PTC) involves organogenesis …
breeding programs for scientific research. Plant tissue culture (PTC) involves organogenesis …
Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease
F Wang, Y Yang, X Lin, JQ Wang, YS Wu… - Human molecular …, 2013 - academic.oup.com
5-Hydroxymethylcytosine (5-hmC) may represent a new epigenetic modification of cytosine.
While the dynamics of 5-hmC during neurodevelopment have recently been reported, little is …
While the dynamics of 5-hmC during neurodevelopment have recently been reported, little is …
Sensitive and simultaneous determination of 5-methylcytosine and its oxidation products in genomic DNA by chemical derivatization coupled with liquid …
Cytosine methylation (5-methylcytosine, 5-mC) in genomic DNA is an important epigenetic
mark that has regulatory roles in diverse biological processes. 5-mC can be oxidized …
mark that has regulatory roles in diverse biological processes. 5-mC can be oxidized …