Cystic kidneys are common causes of end-stage renal disease, both in children and in
adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive …

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Initiation of cyst formation in autosomal dominant polycystic kidney disease (ADPKD) occurs
when kidney tubule cells are rendered null for either PKD1 or PKD2 by somatic 'second …

Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …

Autosomal-dominant polycystic kidney disease (ADPKD) is a disease of defective tissue
homeostasis resulting in active remodeling of nephrons and bile ducts to form fluid-filled …

It is 20 years since the identification of PKD1, the major gene mutated in autosomal
dominant polycystic kidney disease (ADPKD), followed closely by the cloning of PKD2 …

Autosomal dominant polycystic kidney disease (ADPKD) is a progressive inherited disorder
in which renal tissue is gradually replaced with fluid-filled cysts, giving rise to chronic kidney …

Polycystic kidney disease (PKD) is a commonly inherited disorder characterized by cyst
formation and fibrosis (Wilson, N Engl J Med 350: 151–164, 2004) and is caused by …

Natural extracellular matrices (ECM) are currently being studied as an alternative source for
organ transplantation or as new solutions to treat kidney injuries, which can evolve to end …

Autosomal dominant polycystic kidney disease (ADPKD) is a life-threatening monogenic
disease caused by mutations in PKD1 and PKD2 that encode polycystin 1 (PC1) and …