Natural extracellular matrices (ECM) are currently being studied as an alternative source for
organ transplantation or as new solutions to treat kidney injuries, which can evolve to end …

Nephrotoxicity is a critical adverse event that leads to discontinuation of kinase inhibitor (KI)
treatment. Here we show, through meta-analyses of FDA Adverse Event Reporting System …

Oriented cell division (OCD) and convergent extension (CE) shape developing renal
tubules, and their disruption has been associated with polycystic kidney disease (PKD) …

Primary cilia play counterregulatory roles in cystogenesis—they inhibit cyst formation in the
normal renal tubule but promote cyst growth when the function of polycystins is impaired …

Acute kidney injury (AKI) has gained significant attention following patient safety alerts about
the increased risk of harm to patients, including increased mortality and hospitalization …

Renal tubular cells frequently lose differentiation markers and physiological properties when
propagated in conventional cell culture conditions. Embedding cells in 3D …

Objective. Renal ischemia/reperfusion injury (RI/RI) is the main cause of acute kidney injury.
Total glucosides of paeony (TGP) are a traditional Chinese medicine. This study was aimed …

Autosomal dominant polycystic kidney disease (ADPKD) leads to renal failure. The hallmark
of ADPKD is increased epithelial proliferation, which has been proposed to be due to …

Abstract Polycystin-1 (PC-1) and 2 (PC-2) are the products of the PKD1 and PKD2 genes,
which are mutated in Autosomal Dominant Polycystic Kidney Disease (ADPKD). They form a …

Extracellular matrix (ECM) proteins, including fibronectin, may contribute to the early
development and progression of renal interstitial fibrosis associated with chronic renal …