Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine
metabolism. Physiologic Hcy levels are determined primarily by dietary intake and vitamin …

This overview addresses homocysteine and folate metabolism. Its functions and complexity
are described, leading to explanations why disturbed homocysteine and folate metabolism …

Drastic epigenetic reprogramming takes place during preimplantation development, leading
to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in …

Changes in human DNA methylation patterns are an important feature of cancer
development and progression and a potential role in other conditions such as …

This review focuses on how environmental factors through epigenetics modify disease risk
and health outcomes. Major epigenetic events, such as histone modifications, DNA …

Background Altered patterns of gene expression mediate the effects of particulate matter
(PM) on human health, but mechanisms through which PM modifies gene expression are …

Endometriosis is a gynecological disease characterized by the presence of endometrial
glandular epithelial and stromal cells growing in the extra-uterine environment. The disease …

This review provides a brief description of folate use and folic acid metabolism in relation to
neural tube defect (NTD) risk. First, a meta‐analysis of reduction in NTD recurrence and …

The dynamic changes in the epigenome resulting from the intricate interactions of genetic
and environmental factors play crucial roles in individual growth and development …

DNA methylation is an important epigenetic modification that regulates development of
plants and mammals. To investigate the roles of DNA methylation in fungal development, we …