Introduction Poly (ADP-ribose) polymerase inhibitors (PARPis) are an exciting class of
agents that have shown efficacy, particularly for BRCA-mutant triple-negative breast cancer …

The maintenance of epigenetic characteristics is essential for the normal growth and
development of organisms. The maintenance of DNA methylation is an important way to …

The field of epigenetics studies the complex processes that regulate gene expression
without altering the DNA sequence itself. It is well established that epigenetic modifications …

Immunotherapy represented by anti-PD-(L) 1 and anti-CTLA-4 inhibitors has revolutionized
cancer treatment, but challenges related to resistance and toxicity still remain. Due to the …

Tumor endothelial cells (TECs) reside in the inner lining of blood vessels and represent a
promising target for targeted cancer therapy. DNA methylation is a chemical process that …

Introduction Gastric cancer (GC) is the fifth most common malignancy in the world and
accounts for 7.7% of all cancer-related deaths. Early diagnosis of GC is critical in terms of …

In epigenetic mechanisms, DNA methyltransferase 3 alpha (DNMT3A) acts as an initiator for
DNA methylation and prevents the downstream genes from expressing. Perturbations of …

DNA methylation is a key epigenetic regulatory mechanism that plays a critical role in a
variety of cellular processes, including the regulation of cell fate during development …

DNA methyltransferase inhibitors (DNMTi), most commonly cytidine analogs, are
compounds that decrease 5'-cytosine methylation. DNMTi are used clinically based on the …

The role of DNA methylation in mollusks is just beginning to be understood. This review
synthesizes current knowledge on this potent molecular hallmark of epigenetic control in …