DNA methyltransferases and their roles in tumorigenesis
W Zhang, J Xu - Biomarker research, 2017 - Springer
DNA methylation plays an important role in gene expression, chromatin stability, and genetic
imprinting. In mammals, DNA methylation patterns are written and regulated by DNA …
imprinting. In mammals, DNA methylation patterns are written and regulated by DNA …
Extramedullary hematopoiesis of the liver and spleen
D Cenariu, S Iluta, AA Zimta, B Petrushev… - Journal of clinical …, 2021 - mdpi.com
Hematopoiesis is the formation of blood cellular components and, consequently, immune
cells. In a more complete definition, this process refers to the formation, growth, maturation …
cells. In a more complete definition, this process refers to the formation, growth, maturation …
DNMT3A mutations define a unique biological and prognostic subgroup associated with cytotoxic T cells in PTCL-NOS
Peripheral T-cell lymphomas (PTCLs) are heterogenous T-cell neoplasms often associated
with epigenetic dysregulation. We investigated de novo DNA methyltransferase 3A …
with epigenetic dysregulation. We investigated de novo DNA methyltransferase 3A …
Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis
Ten-eleven translocation (Tet) enzymes promote DNA demethylation by oxidizing 5-
methylcytosine. They are expressed during development and are essential for mouse …
methylcytosine. They are expressed during development and are essential for mouse …
DNA methylation: a saga of genome maintenance in hematological perspective
S Chattopadhyaya, S Ghosal - Human Cell, 2022 - Springer
In recent years, an explosion of interest for genome methylation in hematopoietic stem cells
(HSCs) differentiation and transplantation has been observed. The differentiation and timely …
(HSCs) differentiation and transplantation has been observed. The differentiation and timely …
Epigenetics in normal and malignant hematopoiesis: An overview and update 2017
S Goyama, T Kitamura - Cancer science, 2017 - Wiley Online Library
Epigenetic regulation in hematopoiesis has been a field of rapid expansion. Genome‐wide
analyses have revealed, and will continue to identify genetic alterations in epigenetic genes …
analyses have revealed, and will continue to identify genetic alterations in epigenetic genes …
Epigenetic mechanisms of cell adhesion-mediated drug resistance in multiple myeloma
Y Furukawa, J Kikuchi - International journal of hematology, 2016 - Springer
Multiple myeloma cells acquire the resistance to anti-cancer drugs through physical and
functional interactions with the bone marrow microenvironment via two overlapping …
functional interactions with the bone marrow microenvironment via two overlapping …
Cigarette heavy smoking alters DNA methylation patterns and gene transcription levels in humans spermatozoa
MM Laqqan, MM Yassin - Environmental Science and Pollution Research, 2022 - Springer
Tobacco smoking is considered the most common reason of death and infertility around the
world. This study was designed to assess the impact of tobacco heavy smoking on sperm …
world. This study was designed to assess the impact of tobacco heavy smoking on sperm …
Toward clinical application of leukocyte counts based on targeted DNA methylation analysis
S Sontag, L Bocova, WHG Hubens… - Clinical …, 2022 - academic.oup.com
Background Differential leukocyte counts are usually measured based on cellular
morphology or surface marker expression. It has recently been shown that leukocyte counts …
morphology or surface marker expression. It has recently been shown that leukocyte counts …
Long non-coding RNAs in the regulation of myeloid cells
Long non-coding RNAs (lncRNAs) have been attracting immense research interests. The
relevance of lncRNAs in biological and physiological as well as in pathological processes …
relevance of lncRNAs in biological and physiological as well as in pathological processes …