With increasing life expectations, more and more patients suffer from fractures either
induced by intensive sports or other bone-related diseases. The balance between …

Aging research has undergone unprecedented advances at an accelerating rate in recent
years, leading to excitement in the field as well as opportunities for imagination and …

The transcription factors Runx2 and Osx (Osterix) are required for osteoblast differentiation
and bone formation. Runx2 expression occurs at early stages of osteochondroprogenitor …

Mesenchymal stem cells (MSCs) are characterized by their self-renewing capacity and
differentiation potential into multiple tissues. Thus, management of the differentiation …

Abstract Purpose of Review Although many signalling pathways have been discovered to be
essential in mesenchymal stem/stromal (MSC) differentiation, it has become increasingly …

The bone tissue is a dynamic complex that constitutes of several interdependent systems
and is continuously remodeled through the concerted actions of bone cells. Osteoblasts are …

Epigenetic mechanisms regulate osteogenic lineage differentiation of mesenchymal stromal
cells. Histone methylation is controlled by multiple lysine demethylases and is an important …

Post-translational modifications of chromatin such as DNA methylation and different types of
histone acetylation, methylation and phosphorylation are well-appreciated epigenetic …

Age‐related bone loss is in large part the consequence of senescence mechanisms that
impact bone cell number and function. In recent years, progress has been made in the …

Multipotent mesenchymal stromal cells (MSCs) are critical for regeneration of multiple
tissues. Epigenetic mechanisms are fundamental regulators of lineage specification and cell …