Recent advances of osterix transcription factor in osteoblast differentiation and bone formation
Q Liu, M Li, S Wang, Z Xiao, Y Xiong… - Frontiers in cell and …, 2020 - frontiersin.org
With increasing life expectations, more and more patients suffer from fractures either
induced by intensive sports or other bone-related diseases. The balance between …
induced by intensive sports or other bone-related diseases. The balance between …
The spectrum of fundamental basic science discoveries contributing to organismal aging
JN Farr, M Almeida - Journal of Bone and Mineral Research, 2018 - academic.oup.com
Aging research has undergone unprecedented advances at an accelerating rate in recent
years, leading to excitement in the field as well as opportunities for imagination and …
years, leading to excitement in the field as well as opportunities for imagination and …
Mitogen-activated protein kinase (MAPK)-regulated interactions between Osterix and Runx2 are critical for the transcriptional osteogenic program
N Artigas, C Ureña, E Rodríguez-Carballo… - Journal of Biological …, 2014 - ASBMB
The transcription factors Runx2 and Osx (Osterix) are required for osteoblast differentiation
and bone formation. Runx2 expression occurs at early stages of osteochondroprogenitor …
and bone formation. Runx2 expression occurs at early stages of osteochondroprogenitor …
Histone methyltransferases and demethylases: regulators in balancing osteogenic and adipogenic differentiation of mesenchymal stem cells
Mesenchymal stem cells (MSCs) are characterized by their self-renewing capacity and
differentiation potential into multiple tissues. Thus, management of the differentiation …
differentiation potential into multiple tissues. Thus, management of the differentiation …
Epigenetic regulators of mesenchymal stem/stromal cell lineage determination
D Cakouros, S Gronthos - Current osteoporosis reports, 2020 - Springer
Abstract Purpose of Review Although many signalling pathways have been discovered to be
essential in mesenchymal stem/stromal (MSC) differentiation, it has become increasingly …
essential in mesenchymal stem/stromal (MSC) differentiation, it has become increasingly …
Bone remodeling: histone modifications as fate determinants of bone cell differentiation
SJ Yi, H Lee, J Lee, K Lee, J Kim, Y Kim… - International journal of …, 2019 - mdpi.com
The bone tissue is a dynamic complex that constitutes of several interdependent systems
and is continuously remodeled through the concerted actions of bone cells. Osteoblasts are …
and is continuously remodeled through the concerted actions of bone cells. Osteoblasts are …
Lysine-Specific Demethylase 1 (LSD1) epigenetically controls osteoblast differentiation
P Rummukainen, K Tarkkonen, A Dudakovic… - PLoS …, 2022 - journals.plos.org
Epigenetic mechanisms regulate osteogenic lineage differentiation of mesenchymal stromal
cells. Histone methylation is controlled by multiple lysine demethylases and is an important …
cells. Histone methylation is controlled by multiple lysine demethylases and is an important …
Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease
Post-translational modifications of chromatin such as DNA methylation and different types of
histone acetylation, methylation and phosphorylation are well-appreciated epigenetic …
histone acetylation, methylation and phosphorylation are well-appreciated epigenetic …
Bone cell senescence: mechanisms and perspectives
PJ Marie - Journal of Bone and Mineral Research, 2014 - academic.oup.com
Age‐related bone loss is in large part the consequence of senescence mechanisms that
impact bone cell number and function. In recent years, progress has been made in the …
impact bone cell number and function. In recent years, progress has been made in the …
Chromatin dynamics regulate mesenchymal stem cell lineage specification and differentiation to osteogenesis
Multipotent mesenchymal stromal cells (MSCs) are critical for regeneration of multiple
tissues. Epigenetic mechanisms are fundamental regulators of lineage specification and cell …
tissues. Epigenetic mechanisms are fundamental regulators of lineage specification and cell …