Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Gene-editing technologies, which include the CRISPR–Cas nucleases 1, 2, 3 and CRISPR
base editors 4, 5, have the potential to permanently modify disease-causing genes in …

Background A polypill that includes key medications associated with improved outcomes
(aspirin, angiotensin-converting–enzyme [ACE] inhibitor, and statin) has been proposed as …

Human respiratory virus infections lead to a spectrum of respiratory symptoms and disease
severity, contributing to substantial morbidity, mortality and economic losses worldwide, as …

Importance Observational studies have consistently proposed cardiovascular benefits
associated with light alcohol consumption, while recent genetic analyses (ie, mendelian …

The 2020 report of The Lancet Countdown on health and climate change: responding to
converging crises - The Lancet Skip to Main Content Advertisement The Lancet Journal This …

Abstract Background Cardiovascular diseases (CVDs) are one of the global leading causes
of concern due to the rising prevalence and consequence of mortality and disability with a …

Infectious diseases are a major driver of morbidity and mortality globally. Treatment of
malaria, tuberculosis and human immunodeficiency virus infection are particularly …

Chronic obstructive pulmonary disease (COPD) was traditionally thought to be caused by
tobacco smoking. However, recognition of the importance of non-smoking-related risk …

Importance Preterm birth complications are the leading cause of death in children younger
than 5 years worldwide. Despite advancing knowledge of risk factors and mechanisms …