Objective Obesity and its associated comorbidities represent a global health challenge with
a need for well-tolerated, effective, and mechanistically diverse pharmaceutical …

Background More than 90% of the adult population globally is chronically infected by the
Epstein–Barr virus (EBV). It is well established that EBV is associated with a number of …

Background Analysing trends and levels of the burden of disease at the national level can
mask inequalities in health-related progress in lower administrative units such as provinces …

Background To our knowledge, no previous study has prospectively documented the
incidence of common diseases and related mortality in high-income countries (HICs), middle …

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a
systematic analysis for the Glo Page 1 Global Health Metrics 1204 www.thelancet.com Vol 396 …

The worldwide burden of kidney disease is rising, but public awareness remains limited,
underscoring the need for more effective communication by stakeholders in the kidney …

The sixth update of the Canadian Stroke Best Practice Recommendations: Rehabilitation,
Recovery, and Reintegration following Stroke. Part one: Rehabilitation and Recovery …

HIV/AIDS is a leading cause of disease burden in sub-Saharan Africa. Existing evidence has
demonstrated that there is substantial local variation in the prevalence of HIV; however …

The impact of COVID-19 across health services, including treatment services for people who
use drugs, is emerging but likely to have a high impact. Treatment services for people who …

We summarise the evidence for medicinal uses of opioids, harms related to the extramedical
use of, and dependence on, these drugs, and a wide range of interventions used to address …