Background Chimeric antigen receptor engineered T cells (CAR-T) have demonstrated
extraordinary efficacy in B cell malignancy therapy and have been approved by the US Food …

Simple Summary The degree of differentiation of leukemic cells seen in clinical practice is
significant. The dissimilarities concern morphology, cytogenetics, and immunophenotype …

The molecular landscape of chronic lymphocytic leukemia (CLL) has been extensively
characterized, and various potent prognostic biomarkers were discovered. The genetic …

We herein report an innovative antisense approach based on Peptide Nucleic Acids (PNAs)
to down-modulate CD5 expression levels in chronic lymphocytic leukemia (CLL). Using …

In the past 20 years, the interest for the tumor microenvironment (TME) has exponentially
increased. Indeed, it is now commonly admitted that the TME plays a crucial role in cancer …

Assessment of the immunophenotype plays a crucial role in the diagnostic process of
chronic lymphocytic leukemia (CLL). The expression of CD5, CD19 and CD23 antigens with …

Response of chronic lymphocytic leukemia (CLL) patients to classical chemoimmunotherapy
that remains the main strategy in treatment of this disease is strikingly variable. This issue …

In the past 20 years, the interest for the tumor microenvironment (TME) has exponentially
increased. Indeed, it is now commonly admitted that the TME plays a crucial role in cancer …

B-cell Receptor (BCR) signalling plays a critical role in the progression of Chronic
Lymphocytic Leukaemia (CLL) and BCR-targeted kinase inhibitors, such as ibrutinib and …

The interactions between chronic lymphocytic leukaemia (CLL) cells and the CLL
microenvironment play an important role in the disease progression and development of …