Purpose Insomnia is problematic for older adults. After behavioral modifications fail to show
adequate response, pharmacologic options are used. The pharmacokinetics of agents used …

Aging involves progressive impairments in the functional reserve of multiple organs, which
might also affect drug metabolism and pharmacokinetics. In addition, the elderly population …

Background Remimazolam (CNS 7056) is a new ultra–short-acting benzodiazepine for
intravenous sedation and anesthesia. Its pharmacokinetics and pharmacodynamics have …

Population aging evokes doomsday economic and sociological prognostication, despite a
minority of older people suffering significant dependency and the potential for advances in …

Background. Falls in older people are associated with poor prognosis. Medication use is a
potential cause of falls. Our aim was to systemically review all original articles examining …

Aging is known to be associated with an increased prevalence of multiple chronic diseases,
which frequently causes the use of complex therapeutic regimens. The aging process is …

Since 1975, Robert Julien's A Primer of Drug Action has been the definitive guide to the
effects of psychoactive drugs on the brain and on behavior. Now fully updated, this popular …

Ageing is characterized by a progressive decline in the functional reserve of multiple organs
and systems, which can influence drug disposition. In addition, comorbidity and …

Background The authors hypothesized that the electroencephalogram (EEG) during higher
anesthetic concentrations would show more" order" and less" randomness" than at lower …

Cytochrome P450s (CYPs) are an important family of enzymes in the metabolism of many
therapeutic agents and endogenous metabolic reactions. The CYP3A subfamily is …