Mass spectrometry (MS)-based proteomics has become a powerful technology to quantify
the entire complement of proteins in cells or tissues. Here, we review challenges and recent …

Proteins are the main targets of most drugs; however, system-wide methods to monitor
protein activity and function are still underused in drug discovery. Novel biochemical …

Implementing precision medicine hinges on the integration of omics data, such as
proteomics, into the clinical decision-making process, but the quantity and diversity of …

Genomic analyses in cancer have been enormously impactful, leading to the identification of
driver mutations and development of targeted therapies. But the functions of the vast majority …

The use of multiple omics techniques (ie, genomics, transcriptomics, proteomics, and
metabolomics) is becoming increasingly popular in all facets of life science. Omics …

Salinity is detrimental to plant growth, crop production and food security worldwide. Excess
salt triggers increases in cytosolic Ca2+ concentration, which activate Ca2+-binding proteins …

Cancer biomarkers have transformed current practices in the oncology clinic. Continued
discovery and validation are crucial for improving early diagnosis, risk stratification, and …

A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic
constraints imposed by the serine and glycine–limited brain environment restrict metastatic …

Adipocytes are critical for ovarian cancer cells to home to the omentum, but the metabolic
changes initiated by this interaction are unknown. To this end, we carried out unbiased mass …

Many gene products exhibit great structural heterogeneity because of an array of
modifications. These modifications are not directly encoded in the genomic template but …