Genome editing technologies, particularly those based on zinc-finger nucleases (ZFNs),
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …

Although there has been a renewed interest in the field of cancer metabolism in the last
decade, the link between metabolism and DNA damage/DNA repair in cancer has yet to be …

Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …

The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure,
transcription, and genomic integrity, plays key roles in a wide variety of processes in the …

Human cartilage is a complex tissue of matrix proteins that vary in amount and orientation
from superficial to deep layers and from loaded to unloaded zones. A major challenge to …

Abstract Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of
the renin–angiotensin system (RAS). Ang-(1–7) appears to play a central role in the RAS …

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1), also referred to as ADP-
ribosyltransferase Diphtheria toxin-like 1 (ARTD1), is an abundant nuclear protein that plays …

Protein ADP-ribosylation is an ancient posttranslational modification with high biochemical
complexity. It alters the function of modified proteins or provides a scaffold for the recruitment …

Cadmium is a human carcinogen that likely acts via epigenetic mechanisms. Since DNA
methylation alterations represent an important epigenetic event linked to cancer, the effect of …

Nicotinamide (NAM) at doses far above those recommended for vitamins is suggested to be
effective against a wide spectrum of diseases and conditions, including neurological …