Atypical hemolytic uremic syndrome (aHUS) emerged during the last decade as a disease
largely of complement dysregulation. This advance facilitated the development of novel …

Thrombotic thrombocytopenic purpura (TTP; also known as Moschcowitz disease) is
characterized by the concomitant occurrence of often severe thrombocytopenia …

In addition to protective “immune response”, sepsis is characterized by destructive
“endothelial response” of the host, leading to endotheliopathy and its molecular dysfunction …

Transplant-associated thrombotic microangiopathy (TA-TMA) occurs frequently after
hematopoietic stem cell transplantation (HSCT) and can lead to significant morbidity and …

Thrombotic microangiopathy (TMA) after hematopoietic stem cell transplantation (HSCT)
associated with terminal complement activation, as measured by elevated plasma terminal …

Thrombotic microangiopathy (TMA) is a rare but severe disorder characterized by
endothelial cell activation and thrombus formation. It manifests with the triad of hemolytic …

Throughout evolution, organisms have developed means to contain wounds by
simultaneously limiting bleeding and eliminating pathogens and damaged host cells via the …

Kidney diseases resulting from abnormal control of the complement alternative pathway
include atypical hemolytic uremic syndrome, C3 glomerulonephritis, and dense-deposit …

Atypical hemolytic uremic syndrome (aHUS) is a genetic ultrarare renal disease associated
with overactivation of the alternative pathway of complement. Four gain-of-function …

Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy (TMA)
characterized by excessive activation of the alternative pathway of complement (APC) …