Purpose Chronic kidney disease (CKD) is a major health-care burden. Increasing evidence
suggests that a considerable proportion of patients are affected by a monogenic kidney …

Atypical hemolytic uremic syndrome (aHUS) is a genetic ultrarare renal disease associated
with overactivation of the alternative pathway of complement. Four gain-of-function …

TTP is characterized by microangiopathic hemolytic anemia and thrombocytopenia
associated with brain and kidney dysfunction. It occurs due to ADAMTS13 deficiency. TTP …

Atypical hemolytic uremic syndrome (aHUS) is a complementmediated thrombotic
microangiopathy (TMA) characterized by mechanical hemolysis, renal impairment …

Thrombocytopenia affects 25–55% of intensive care unit (ICU) patients [1]. The reasons for
thrombocytopenia in the ICU are numerous, including, among others, sepsis, drugs, and the …

Several complement proteins interact with hemostatic factors. We discovered that von
Willebrand factor (VWF) acts as a cofactor for factor I–mediated cleavage of complement …

Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy (TMA) that
affects multiple organs and the kidneys in particular. aHUS can be sporadic or familial and is …

Background Atypical hemolytic uremic syndrome (aHUS) is a chronic disease characterized
by thrombotic microangiopathy and a high risk of end-stage kidney disease. Dysregulation …

Thrombotic microangiopathies are rare disorders characterized by the concomitant
occurrence of severe thrombocytopenia, microangiopathic hemolytic anemia, and a variable …

Thrombotic microangiopathies (TMAs) have in common a terminal phenotype of
microangiopathic hemolytic anemia with end-organ dysfunction. Thrombotic …