[HTML][HTML] The underestimated burden of monogenic kidney disease in adults waitlisted for kidney transplantation
E Schrezenmeier, E Kremerskothen, F Halleck… - Genetics in …, 2021 - Elsevier
Purpose Chronic kidney disease (CKD) is a major health-care burden. Increasing evidence
suggests that a considerable proportion of patients are affected by a monogenic kidney …
suggests that a considerable proportion of patients are affected by a monogenic kidney …
Complement factor B mutations in atypical hemolytic uremic syndrome—disease-relevant or benign?
MC Marinozzi, L Vergoz, T Rybkine, S Ngo… - Journal of the …, 2014 - journals.lww.com
Atypical hemolytic uremic syndrome (aHUS) is a genetic ultrarare renal disease associated
with overactivation of the alternative pathway of complement. Four gain-of-function …
with overactivation of the alternative pathway of complement. Four gain-of-function …
[HTML][HTML] TTP-like syndrome: novel concept and molecular pathogenesis of endotheliopathy-associated vascular microthrombotic disease
JC Chang - Thrombosis journal, 2018 - Springer
TTP is characterized by microangiopathic hemolytic anemia and thrombocytopenia
associated with brain and kidney dysfunction. It occurs due to ADAMTS13 deficiency. TTP …
associated with brain and kidney dysfunction. It occurs due to ADAMTS13 deficiency. TTP …
Eculizumab cessation in atypical hemolytic uremic syndrome
SA Merrill, ZD Brittingham, X Yuan… - Blood, The Journal …, 2017 - ashpublications.org
Atypical hemolytic uremic syndrome (aHUS) is a complementmediated thrombotic
microangiopathy (TMA) characterized by mechanical hemolysis, renal impairment …
microangiopathy (TMA) characterized by mechanical hemolysis, renal impairment …
[HTML][HTML] Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies—what intensivists need to know
Thrombocytopenia affects 25–55% of intensive care unit (ICU) patients [1]. The reasons for
thrombocytopenia in the ICU are numerous, including, among others, sepsis, drugs, and the …
thrombocytopenia in the ICU are numerous, including, among others, sepsis, drugs, and the …
von Willebrand factor is a cofactor in complement regulation
Several complement proteins interact with hemostatic factors. We discovered that von
Willebrand factor (VWF) acts as a cofactor for factor I–mediated cleavage of complement …
Willebrand factor (VWF) acts as a cofactor for factor I–mediated cleavage of complement …
Atypical hemolytic uremic syndrome
V Afshar-Kharghan - Hematology 2014, the American Society …, 2016 - ashpublications.org
Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy (TMA) that
affects multiple organs and the kidneys in particular. aHUS can be sporadic or familial and is …
affects multiple organs and the kidneys in particular. aHUS can be sporadic or familial and is …
Extra-Renal manifestations of atypical hemolytic uremic syndrome in children
K Fidan, N Göknar, B Gülhan, E Melek, ZY Yıldırım… - Pediatric …, 2018 - Springer
Background Atypical hemolytic uremic syndrome (aHUS) is a chronic disease characterized
by thrombotic microangiopathy and a high risk of end-stage kidney disease. Dysregulation …
by thrombotic microangiopathy and a high risk of end-stage kidney disease. Dysregulation …
[HTML][HTML] Pathophysiology of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
JAK Hovinga, SR Heeb, M Skowronska… - Journal of thrombosis …, 2018 - Elsevier
Thrombotic microangiopathies are rare disorders characterized by the concomitant
occurrence of severe thrombocytopenia, microangiopathic hemolytic anemia, and a variable …
occurrence of severe thrombocytopenia, microangiopathic hemolytic anemia, and a variable …
Thrombotic Microangiopathy Syndromes—Common Ground and Distinct Frontiers
RM Hanna, K Henriksen, K Kalantar-Zadeh… - Advances in chronic …, 2022 - Elsevier
Thrombotic microangiopathies (TMAs) have in common a terminal phenotype of
microangiopathic hemolytic anemia with end-organ dysfunction. Thrombotic …
microangiopathic hemolytic anemia with end-organ dysfunction. Thrombotic …