Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

BACKGROUND Infertility and pregnancy loss are longstanding problems. Successful
fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies …

Human in vitro fertilized embryos exhibit low developmental capabilities, and the
mechanisms that underlie embryonic arrest remain unclear. Here using a single-cell multi …

During pre-implantation stages of mammalian development, maternally stored material
promotes both the erasure of the sperm and oocyte epigenetic profiles and is responsible for …

A well-orchestrated program of oocyte growth and differentiation results in a
developmentally competent oocyte. In late oogenesis, germinal vesicle oocytes (GVOs) …

Low cloning efficiency limits the wide application of somatic cell nuclear transfer technology.
Apoptosis and incomplete DNA methylation reprogramming of pluripotency genes are …

Mammalian development commences with the zygote, which can differentiate into both
embryonic and extraembryonic tissues, a capability known as totipotency. Only the zygote …

Multi-locus methylation defects (MLMDs) in imprinted loci have been reported in Beckwith-
Wiedemann Syndrome (BWS). Large offspring syndrome (LOS), a phenotypic subgroup of …

Global methylation levels differ in in vitro-and in vivo-developed embryos. Follicular fluid
(FF) contains extracellular vesicles (EVs) containing miRNAs that affect embryonic …

DNA 甲基化(DNA methylation) 是一种动态, 可逆并可以遗传的表观遗传修饰模式,
主要发生在哺乳动物原始生殖细胞和早期胚胎发育过程中, 能够通过高动态和协同的核酶网络 …