The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …

Effective drug therapy to optimally influence disease requires an understanding of a drug's
pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships. In …

The release and absorption profile of an oral medication is influenced by the
physicochemical properties of the drug and its formulation, as well as by the anatomy and …

Developmental changes in children can affect the disposition and clinical effects of a drug,
indicating that scaling an adult dose simply down per linear weight can potentially lead to …

The small intestine provides the major site for the absorption of numerous orally
administered drugs. However, before reaching to the systemic circulation to exert beneficial …

Background Preterm neonates are usually not part of a traditional drug development
programme, however they are frequently administered medicines. Developing modelling …

The limit for possible survival after extremely preterm birth has steadily improved and
consequently, more premature neonates with increasingly lower gestational age at birth now …

In premature infants, effective and safe drug therapy depends on optimal dose selection and
requires a thorough understanding of the underlying disease (s) of these fragile infants as …

Abstract The cytochrome P450 (CYP450) superfamily is responsible for the metabolism of
most xenobiotics and pharmacological treatments generally used in clinical settings. Genetic …

Characterising the small intestine absorptive membrane is essential to enable prediction of
the systemic exposure of oral formulations. In particular, the ontogeny of key intestinal Drug …