The concept of an epigenetic landscape describing potential cellular fates arising from
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …

Over the course of a human lifespan, genome integrity erodes, leading to an increased
abundance of several types of chromatin changes. The abundance of DNA lesions …

Adjacent CpG sites in mammalian genomes can be co-methylated owing to the processivity
of methyltransferases or demethylases, yet discordant methylation patterns have also been …

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …

DNA methylation is an epigenetic mark that has suspected regulatory roles in a broad range
of biological processes and diseases. The technology is now available for studying DNA …

Abstract DNA methylation, through 5-methyl-and 5-hydroxymethylcytosine (5mC and 5hmC),
is considered to be one of the principal interfaces between the genome and our …

The combination of DNA bisulfite treatment with high-throughput sequencing technologies
has enabled investigation of genome-wide DNA methylation at near base pair level …

DNA and Histone 3 Lysine 27 methylation typically function as repressive modifications and
operate within distinct genomic compartments. In mammals, the majority of the genome is …

DNA methylation in repetitive elements (RE) suppresses their mobility and maintains
genomic stability, and decreases in it are frequently observed in tumor and/or surrogate …

Epigenetic changes in long interspersed nuclear element-1s (LINE-1s or L1s) occur early
during the process of carcinogenesis. A lower methylation level (hypomethylation) of LINE-1 …