Pathogenesis and management of abdominal aortic aneurysm

J Golledge, S Thanigaimani, JT Powell… - European Heart …, 2023 - academic.oup.com
Abdominal aortic aneurysm (AAA) causes∼ 170 000 deaths annually worldwide. Most
guidelines recommend asymptomatic small AAAs (30 to< 50 mm in women; 30 to< 55 mm in …

[HTML][HTML] Editor's choice--European Society for Vascular Surgery (ESVS) 2024 clinical practice guidelines on the management of abdominal aorto-iliac artery …

A Wanhainen, I Van Herzeele, FB Goncalves… - European Journal of …, 2024 - Elsevier
Abstract Objective The European Society for Vascular Surgery (ESVS) has developed
clinical practice guidelines for the care of patients with aneurysms of the abdominal aorta …

Metformin: evidence from preclinical and clinical studies for potential novel applications in cardiovascular disease

A Dihoum, G Rena, ER Pearson, CC Lang… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction For a long time, metformin has been the first-line treatment for glycemic control
in type 2 diabetes; however, the results of recent cardiovascular outcome trials of sodium …

Protection of diabetes in aortic abdominal aneurysm: Are antidiabetics the real effectors?

B Picatoste, I Cerro-Pardo, LM Blanco-Colio… - Frontiers in …, 2023 - frontiersin.org
Aortic aneurysms, including abdominal aortic aneurysms (AAAs), is the second most
prevalent aortic disease and represents an important cause of death worldwide. AAA is a …

Therapeutic potential of natural products and underlying targets for the treatment of aortic aneurysm

W Zhao, B Li, J Hao, R Sun, P He, H Lv, M He… - Pharmacology & …, 2024 - Elsevier
Aortic aneurysm is a vascular disease characterized by irreversible vasodilatation that can
lead to dissection and rupture of the aortic aneurysm, a life-threatening condition. Thoracic …

The effect of diabetes on abdominal aortic aneurysm growth–updated systematic review and meta-analysis

LH Alawattegama, M Gaddah, L Kimani, GA Antoniou - Vasa, 2024 - econtent.hogrefe.com
Studies have shown that diabetes mellitus is associated with a reduced prevalence and
growth of abdominal aortic aneurysms (AAA). Establishing the factors that influence AAA …

Metformin Use and Long-term Outcomes Including Aneurysm Sac Dynamics Following EVAR for Infrarenal Abdominal Aortic Aneurysm:“A Retrospective Study”

OLRM van Tongeren, V Rastogi… - Journal of …, 2024 - journals.sagepub.com
Purpose: Metformin, widely used for the treatment of diabetes mellitus (DM), has shown
potential for inhibiting abdominal aortic aneurysm (AAA) growth by reducing extracellular …

Association between Diabetes Status and Long-term Outcomes Following Open and Endovascular Repair of Infrarenal Abdominal Aortic Aneurysms

V Rastogi, SP Summers, SD Yadavalli, J Perrier… - Journal of Vascular …, 2024 - Elsevier
Objective Current literature reports conflicting findings regarding the effect of diabetes
mellitus (DM) on outcomes of AAA repair. In this study we examined the effect of DM and its …

Could Metformin use reduce abdominal aortic aneurysm risk? A Mendelian randomisation study using known Metformin targets

KL Saxby, F Dudbridge, NJ Samani, MJ Bown… - medRxiv, 2023 - medrxiv.org
Introduction An abdominal aortic aneurysm (AAA) is a swelling of the main artery in the body
estimated to affect 0.92% of adults (aged 30-79) worldwide. Rupture is often fatal and …

Clinical utility of genomic analyses and polygenic risk scores for aortic diseases

C Gellatly, MJ Bown - Nature Cardiovascular Research, 2022 - nature.com
Rupture or dissection of the aorta is often fatal. Tcheandjieu and colleagues now identify key
pathways underlying aortic dilatation, a common prelude to acute aortic events, and assess …