Epigenome‐wide association study of BMI in Black populations from InterGEN and GENOA
Objective Obesity is a significant public health concern across the globe. Research
investigating epigenetic mechanisms related to obesity and obesity‐associated conditions …
investigating epigenetic mechanisms related to obesity and obesity‐associated conditions …
Accelerated epigenetic age is associated with whole-brain functional connectivity and impaired cognitive performance in older adults
While chronological age is a strong predictor for health-related risk factors, it is an
incomplete metric that fails to fully characterize the unique aging process of individuals with …
incomplete metric that fails to fully characterize the unique aging process of individuals with …
3D chromatin remodeling potentiates transcriptional programs driving cell invasion
B Lebeau, M Jangal, T Zhao… - Proceedings of the …, 2022 - National Acad Sciences
The contribution of deregulated chromatin architecture, including topologically associated
domains (TADs), to cancer progression remains ambiguous. CCCTC-binding factor (CTCF) …
domains (TADs), to cancer progression remains ambiguous. CCCTC-binding factor (CTCF) …
eUTOPIA: solUTion for Omics data PreprocessIng and Analysis
Background Application of microarrays in omics technologies enables quantification of many
biomolecules simultaneously. It is widely applied to observe the positive or negative effect …
biomolecules simultaneously. It is widely applied to observe the positive or negative effect …
Prenatal alcohol exposure is associated with adverse cognitive effects and distinct whole-genome DNA methylation patterns in primary school children
S Frey, A Eichler, V Stonawski, J Kriebel… - Frontiers in behavioral …, 2018 - frontiersin.org
Prenatal alcohol exposure (PAE) is known to elicit a broad range of systemic effects,
including neurophysiological alterations that result in adverse behavioral and cognitive …
including neurophysiological alterations that result in adverse behavioral and cognitive …
Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system
Antidepressants are an effective treatment for major depressive disorder (MDD), although
individual response is unpredictable and highly variable. Whilst the mode of action of …
individual response is unpredictable and highly variable. Whilst the mode of action of …
[HTML][HTML] Genome-Wide Methylation Profiling in 229 Patients With Crohn's Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post …
Background & Aims DNA methylation alterations may provide important insights into gene-
environment interaction in cancer, aging, and complex diseases, such as inflammatory …
environment interaction in cancer, aging, and complex diseases, such as inflammatory …
[HTML][HTML] Assessment of dried blood spots for DNA methylation profiling
RM Walker, L MacGillivray, S McCafferty… - Wellcome Open …, 2019 - ncbi.nlm.nih.gov
Background: DNA methylation reflects health-related environmental exposures and genetic
risk, providing insights into aetiological mechanisms and potentially predicting disease …
risk, providing insights into aetiological mechanisms and potentially predicting disease …
Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans
Target organ damage (TOD) manifests as vascular injuries in the body organ systems
associated with long-standing hypertension. DNA methylation in peripheral blood …
associated with long-standing hypertension. DNA methylation in peripheral blood …
Epigenetic signatures discriminate patients with primary sclerosing cholangitis and ulcerative colitis from patients with ulcerative colitis
M de Krijger, IL Hageman, AYF Li Yim… - Frontiers in …, 2022 - frontiersin.org
Background Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease
affecting the intra-and extrahepatic bile ducts, and is strongly associated with ulcerative …
affecting the intra-and extrahepatic bile ducts, and is strongly associated with ulcerative …