Using saliva epigenetic data to develop and validate a multivariable predictor of esophageal cancer status

TC Stone, V Ward, A Hogan, KM Alexander Ho… - …, 2024 - Taylor & Francis
Background: Salivary epigenetic biomarkers may detect esophageal cancer. Methods: A
total of 256 saliva samples from esophageal adenocarcinoma patients and matched …

Interactive graphics for functional data analyses

J Wrobel, SY Park, AM Staicu, J Goldsmith - Stat, 2016 - Wiley Online Library
Although there are established graphics that accompany the most common functional data
analyses, generating these graphics for each dataset and analysis can be cumbersome and …

methylR: a graphical interface for comprehensive DNA methylation array data analysis

M Volpe, J Das - Bioinformatics, 2023 - academic.oup.com
Motivation DNA methylation analysis using arrays is a widely used method in research and
clinical studies to study Epigenetics. Although several packages have been published to …

Epigenome-wide association study of global cortical volumes in generation Scotland: Scottish family health study

MC Barbu, M Harris, X Shen, S Aleks, C Green… - Epigenetics, 2022 - Taylor & Francis
ABSTRACT A complex interplay of genetic and environmental risk factors influence global
brain structural alterations associated with brain health and disease. Epigenome-wide …

[HTML][HTML] Phenome-wide analyses identify an association between the parent-of-origin effects dependent methylome and the rate of aging in humans

C Gao, C Amador, RM Walker, A Campbell… - Genome Biology, 2023 - Springer
Background The variation in the rate at which humans age may be rooted in early events
acting through the genomic regions that are influenced by such events and subsequently …

Peripheral blood DNA methylation signatures predict response to vedolizumab and ustekinumab in adult patients with Crohn's disease: The EPIC-CD study

VW Joustra, AYF Li Yim, P Henneman, IL Hageman… - medRxiv, 2024 - medrxiv.org
Biological therapeutics are now widely used in Crohn′ s disease (CD), with evidence of
efficacy from randomized trials and real-world experience. Primary non-response is a …

Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets

JI Hoell, S Ginzel, M Kuhlen, A Kloetgen… - Blood …, 2019 - ashpublications.org
Survival of patients with pediatric acute lymphoblastic leukemia (ALL) after allogeneic
hematopoietic stem cell transplantation (allo-SCT) is mainly compromised by leukemia …

Prognostic significance of DNA methylation profiles at MRI enhancing tumor recurrence: a report from the EORTC 26091 TAVAREC trial

K Draaisma, CMS Tesileanu, I de Heer, M Klein… - Clinical Cancer …, 2022 - AACR
Purpose: Despite recent advances in the molecular characterization of gliomas, it remains
unclear which patients benefit most from which second-line treatments. The TAVAREC trial …

Improving pharmacometrics analysis efficiency using DataCheQC: An interactive, Shiny‐based app for quality control of pharmacometrics datasets

O Dotan, A Radivojevic, R Singh - CPT: Pharmacometrics & …, 2023 - Wiley Online Library
DataCheQC is an interactive application based on the R Shiny framework developed for the
purposes of performing quality control (QC) checks on pharmacometric datasets, and …

[HTML][HTML] SNP-by-CpG Site Interactions in ABCA7 Are Associated with Cognition in Older African Americans

DL Chaar, K Nguyen, YZ Wang, SM Ratliff, TH Mosley… - Genes, 2022 - mdpi.com
SNPs in ABCA7 confer the largest genetic risk for Alzheimer's Disease (AD) in African
Americans (AA) after APOE ε4. However, the relationship between ABCA7 and cognitive …