Using saliva epigenetic data to develop and validate a multivariable predictor of esophageal cancer status
TC Stone, V Ward, A Hogan, KM Alexander Ho… - …, 2024 - Taylor & Francis
Background: Salivary epigenetic biomarkers may detect esophageal cancer. Methods: A
total of 256 saliva samples from esophageal adenocarcinoma patients and matched …
total of 256 saliva samples from esophageal adenocarcinoma patients and matched …
Interactive graphics for functional data analyses
Although there are established graphics that accompany the most common functional data
analyses, generating these graphics for each dataset and analysis can be cumbersome and …
analyses, generating these graphics for each dataset and analysis can be cumbersome and …
methylR: a graphical interface for comprehensive DNA methylation array data analysis
Motivation DNA methylation analysis using arrays is a widely used method in research and
clinical studies to study Epigenetics. Although several packages have been published to …
clinical studies to study Epigenetics. Although several packages have been published to …
Epigenome-wide association study of global cortical volumes in generation Scotland: Scottish family health study
ABSTRACT A complex interplay of genetic and environmental risk factors influence global
brain structural alterations associated with brain health and disease. Epigenome-wide …
brain structural alterations associated with brain health and disease. Epigenome-wide …
[HTML][HTML] Phenome-wide analyses identify an association between the parent-of-origin effects dependent methylome and the rate of aging in humans
Background The variation in the rate at which humans age may be rooted in early events
acting through the genomic regions that are influenced by such events and subsequently …
acting through the genomic regions that are influenced by such events and subsequently …
Peripheral blood DNA methylation signatures predict response to vedolizumab and ustekinumab in adult patients with Crohn's disease: The EPIC-CD study
VW Joustra, AYF Li Yim, P Henneman, IL Hageman… - medRxiv, 2024 - medrxiv.org
Biological therapeutics are now widely used in Crohn′ s disease (CD), with evidence of
efficacy from randomized trials and real-world experience. Primary non-response is a …
efficacy from randomized trials and real-world experience. Primary non-response is a …
Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets
JI Hoell, S Ginzel, M Kuhlen, A Kloetgen… - Blood …, 2019 - ashpublications.org
Survival of patients with pediatric acute lymphoblastic leukemia (ALL) after allogeneic
hematopoietic stem cell transplantation (allo-SCT) is mainly compromised by leukemia …
hematopoietic stem cell transplantation (allo-SCT) is mainly compromised by leukemia …
Prognostic significance of DNA methylation profiles at MRI enhancing tumor recurrence: a report from the EORTC 26091 TAVAREC trial
K Draaisma, CMS Tesileanu, I de Heer, M Klein… - Clinical Cancer …, 2022 - AACR
Purpose: Despite recent advances in the molecular characterization of gliomas, it remains
unclear which patients benefit most from which second-line treatments. The TAVAREC trial …
unclear which patients benefit most from which second-line treatments. The TAVAREC trial …
Improving pharmacometrics analysis efficiency using DataCheQC: An interactive, Shiny‐based app for quality control of pharmacometrics datasets
O Dotan, A Radivojevic, R Singh - CPT: Pharmacometrics & …, 2023 - Wiley Online Library
DataCheQC is an interactive application based on the R Shiny framework developed for the
purposes of performing quality control (QC) checks on pharmacometric datasets, and …
purposes of performing quality control (QC) checks on pharmacometric datasets, and …
[HTML][HTML] SNP-by-CpG Site Interactions in ABCA7 Are Associated with Cognition in Older African Americans
SNPs in ABCA7 confer the largest genetic risk for Alzheimer's Disease (AD) in African
Americans (AA) after APOE ε4. However, the relationship between ABCA7 and cognitive …
Americans (AA) after APOE ε4. However, the relationship between ABCA7 and cognitive …