INTRODUCTION The 'epigenetic clock'is a DNA methylation-based estimate of biological
age and is correlated with chronological age–the greatest risk factor for Alzheimer's disease …

Background: Several studies have shown effects of current and maternal smoking during
pregnancy on DNA methylation of CpG sites in newborns and later in life. Here, we …

DNA methylation has been proposed as a potential molecular mechanism linking
environmental risk factors to the development of psychiatric disorders. This thesis presents a …

Complex diseases are multifactorial diseases caused by a complex combination of genetic,
environmental and lifestyle effects. Numerous non-coding regions that increase the risk for …

Aging and psychosocial stress are associated with increased inflammation and disease risk,
but the underlying molecular mechanisms are poorly understood. Because both aging and …

Bacteria and bacterial derived metabolites are known to influence the host epigenetic
regulation patterns such as DNA methylation and histone modifications, thus altering the …

The vast majority of common disease-associated genetic variation is non-coding. However,
the route by which non-coding genetic variation influences disease susceptibility is largely …

The goal of the tutorial is to present a standard analysis workflow of 450K data with the
package minfi, incorporating the functions recently added to the package. We invite you to …

The aim of HELIX is to investigate the effect of early life exposures on child health and to
understand the molecular mechanisms involved in this association, including DNA …

Background: Obesity predisposes to cardiovascular disease, itself influenced by perinatal
factors. Epigenetics is hypothesized to link perinatal influences with later obesity. We aimed …