DNA methylation age acceleration and risk factors for Alzheimer's disease
DL McCartney, AJ Stevenson, RM Walker, J Gibson… - bioRxiv, 2018 - biorxiv.org
INTRODUCTION The 'epigenetic clock'is a DNA methylation-based estimate of biological
age and is correlated with chronological age–the greatest risk factor for Alzheimer's disease …
age and is correlated with chronological age–the greatest risk factor for Alzheimer's disease …
Results: We identified 23 CpGs (genome-wide p level: 1.06× 10− 7) that were associated with maternal smoking during pregnancy, including associated genes AHRR …
S Rauschert, PE Melton, G Burdge… - Epigenetic …, 2020 - books.google.com
Background: Several studies have shown effects of current and maternal smoking during
pregnancy on DNA methylation of CpG sites in newborns and later in life. Here, we …
pregnancy on DNA methylation of CpG sites in newborns and later in life. Here, we …
Epigenetic interactions with genetic and environmental risk factors for schizophrenia and bipolar disorder
O Watkeys - 2021 - unsworks.unsw.edu.au
DNA methylation has been proposed as a potential molecular mechanism linking
environmental risk factors to the development of psychiatric disorders. This thesis presents a …
environmental risk factors to the development of psychiatric disorders. This thesis presents a …
Identification of Potential Molecular Traits Underlying the Genetic Predisposition to Complex diseases Using Multi-omics and Meta-analysis
L Guan - 2021 - deepblue.lib.umich.edu
Complex diseases are multifactorial diseases caused by a complex combination of genetic,
environmental and lifestyle effects. Numerous non-coding regions that increase the risk for …
environmental and lifestyle effects. Numerous non-coding regions that increase the risk for …
[PDF][PDF] Epigenetic derepression of FKBP5 by aging and stress contributes to NF-κB-driven inflammation and cardiovascular risk
AS Zannas, M Jia, K Hafner, J Baumert, T Wiechmann… - scholar.archive.org
Aging and psychosocial stress are associated with increased inflammation and disease risk,
but the underlying molecular mechanisms are poorly understood. Because both aging and …
but the underlying molecular mechanisms are poorly understood. Because both aging and …
Microbiota and Epigenetic Regulation of Inflammatory Mediators
M Remely, H Karlic, I Rebhan, M Greunz… - Epigenetics and Gene …, 2017 - Springer
Bacteria and bacterial derived metabolites are known to influence the host epigenetic
regulation patterns such as DNA methylation and histone modifications, thus altering the …
regulation patterns such as DNA methylation and histone modifications, thus altering the …
On the genetics of intermediate phenotypes and their utility
AD Bretherick - 2020 - era.ed.ac.uk
The vast majority of common disease-associated genetic variation is non-coding. However,
the route by which non-coding genetic variation influences disease susceptibility is largely …
the route by which non-coding genetic variation influences disease susceptibility is largely …
[PDF][PDF] Minfi tutorial BioC2014
JPFKD Hansen - 2014 - m.100ai360.com
The goal of the tutorial is to present a standard analysis workflow of 450K data with the
package minfi, incorporating the functions recently added to the package. We invite you to …
package minfi, incorporating the functions recently added to the package. We invite you to …
[PDF][PDF] DNA methylation data
C Ruiz, JR González, M Bustamante - projecthelix.eu
The aim of HELIX is to investigate the effect of early life exposures on child health and to
understand the molecular mechanisms involved in this association, including DNA …
understand the molecular mechanisms involved in this association, including DNA …
Stability Over Time and Between Generations of Differential DNA Methylation Identified by Epigenome-Wide Association Study of Adolescent Adiposity
Background: Obesity predisposes to cardiovascular disease, itself influenced by perinatal
factors. Epigenetics is hypothesized to link perinatal influences with later obesity. We aimed …
factors. Epigenetics is hypothesized to link perinatal influences with later obesity. We aimed …