Evolution by gene loss
R Albalat, C Cañestro - Nature Reviews Genetics, 2016 - nature.com
The recent increase in genomic data is revealing an unexpected perspective of gene loss as
a pervasive source of genetic variation that can cause adaptive phenotypic diversity. This …
a pervasive source of genetic variation that can cause adaptive phenotypic diversity. This …
Emergence and evolution of virulence in human pathogenic fungi
One billion people worldwide are affected by fungal pathogens, of which 1.6 million
succumb to fungal infections per year. This review discusses the emergence and evolution …
succumb to fungal infections per year. This review discusses the emergence and evolution …
Asymmetrical dose responses shape the evolutionary trade-off between antifungal resistance and nutrient use
PC Després, AF Cisneros, EMM Alexander… - Nature Ecology & …, 2022 - nature.com
Antimicrobial resistance is an emerging threat for public health. The success of resistance
mutations depends on the trade-off between the benefits and costs they incur. This trade-off …
mutations depends on the trade-off between the benefits and costs they incur. This trade-off …
Fungal Inositol Pyrophosphate IP7 Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity
Inositol pyrophosphates (PP-IPs) comprising inositol, phosphate, and pyrophosphate (PP)
are essential for multiple functions in eukaryotes. Their role in fungal pathogens has never …
are essential for multiple functions in eukaryotes. Their role in fungal pathogens has never …
Molecular methods for the diagnosis and characterization of Cryptococcus: a review
Cryptococcosis is a fungal infection caused by yeasts of the genus Cryptococcus, with
Cryptococcus neoformans and Cryptococcus gattii as the primary pathogenic species. This …
Cryptococcus neoformans and Cryptococcus gattii as the primary pathogenic species. This …
A novel specificity protein 1 (SP1)-like gene regulating protein kinase C-1 (Pkc1)-dependent cell wall integrity and virulence factors in Cryptococcus neoformans
Eukaryotic cells utilize complex signaling systems to detect their environments, responding
and adapting as new conditions arise during evolution. The basidiomycete fungus …
and adapting as new conditions arise during evolution. The basidiomycete fungus …
If looks could kill: Fungal macroscopic morphology and virulence
CH Kowalski, RA Cramer - PLoS pathogens, 2020 - journals.plos.org
The complexity and diversity of microbial colony morphologies have contributed to the
identification of pathogenic microbes for decades. Even as biomarker-based approaches …
identification of pathogenic microbes for decades. Even as biomarker-based approaches …
Genomics and evolution of Pneumocystis species
The genus Pneumocystis comprises highly diversified fungal species that cause severe
pneumonia in individuals with a deficient immune system. These fungi infect exclusively …
pneumonia in individuals with a deficient immune system. These fungi infect exclusively …
Isolation and Characterization of Senescent Cryptococcus neoformans and Implications for Phenotypic Switching and Pathogenesis in Chronic Cryptococcosis
N Jain, E Cook, I Xess, F Hasan, D Fries… - Eukaryotic cell, 2009 - Am Soc Microbiol
Although several virulence factors and associated genes have been identified, the
mechanisms that allow Cryptococcus neoformans to adapt during chronic infection and to …
mechanisms that allow Cryptococcus neoformans to adapt during chronic infection and to …
Antivirulence and avirulence genes in human pathogenic fungi
Opportunistic commensal and environmental fungi can cause superficial to systemic
diseases in humans. But how did these pathogens adapt to infect us and how does host …
diseases in humans. But how did these pathogens adapt to infect us and how does host …