[HTML][HTML] Genetic impacts on DNA methylation: research findings and future perspectives
S Villicaña, JT Bell - Genome biology, 2021 - Springer
Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
[HTML][HTML] Genetic–epigenetic interactions in cis: a major focus in the post-GWAS era
Studies on genetic–epigenetic interactions, including the mapping of methylation
quantitative trait loci (mQTLs) and haplotype-dependent allele-specific DNA methylation …
quantitative trait loci (mQTLs) and haplotype-dependent allele-specific DNA methylation …
DNA methylation QTL mapping across diverse human tissues provides molecular links between genetic variation and complex traits
M Oliva, K Demanelis, Y Lu, M Chernoff, F Jasmine… - Nature …, 2023 - nature.com
Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …
specific characterization of DNAm is needed to understand its role in gene regulation and its …
[HTML][HTML] Engineering triangular carbon quantum dots with unprecedented narrow bandwidth emission for multicolored LEDs
F Yuan, T Yuan, L Sui, Z Wang, Z Xi, Y Li, X Li… - Nature …, 2018 - nature.com
Carbon quantum dots (CQDs) have emerged as promising materials for optoelectronic
applications on account of carbon's intrinsic merits of high stability, low cost, and …
applications on account of carbon's intrinsic merits of high stability, low cost, and …
An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome
We report a multi-omic resource generated by applying quantitative trait locus (xQTL)
analyses to RNA sequence, DNA methylation and histone acetylation data from the …
analyses to RNA sequence, DNA methylation and histone acetylation data from the …
[HTML][HTML] DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
The human leukocyte antigen (HLA) haplotype DRB1* 15: 01 is the major risk factor for
multiple sclerosis (MS). Here, we find that DRB1* 15: 01 is hypomethylated and …
multiple sclerosis (MS). Here, we find that DRB1* 15: 01 is hypomethylated and …
Socioeconomic deprivation index is associated with psychiatric disorders: an observational and genome-wide gene-by-environment interaction analysis in the UK …
J Ye, Y Wen, X Sun, X Chu, P Li, B Cheng, S Cheng… - Biological …, 2021 - Elsevier
Background Psychiatric disorders are among the largest and fastest-growing categories of
the global disease burden. However, limited effort has been made to further elucidate …
the global disease burden. However, limited effort has been made to further elucidate …
Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney
The kidney is an organ of key relevance to blood pressure (BP) regulation, hypertension and
antihypertensive treatment. However, genetically mediated renal mechanisms underlying …
antihypertensive treatment. However, genetically mediated renal mechanisms underlying …
[HTML][HTML] A machine learning approach to brain epigenetic analysis reveals kinases associated with Alzheimer's disease
Alzheimer's disease (AD) is influenced by both genetic and environmental factors; thus,
brain epigenomic alterations may provide insights into AD pathogenesis. Multiple array …
brain epigenomic alterations may provide insights into AD pathogenesis. Multiple array …
Developmental programming of obesity and diabetes in mouse, monkey, and man in 2018: where are we headed?
JE Friedman - Diabetes, 2018 - Am Diabetes Assoc
Childhood obesity and its comorbidities continue to accelerate across the globe. Two-thirds
of pregnant women are obese/overweight, as are 20% of preschoolers. Gestational diabetes …
of pregnant women are obese/overweight, as are 20% of preschoolers. Gestational diabetes …