Ten-eleven translocation (TET) methylcytosine dioxygenases (TET1, TET2, TET3) actively
cause demethylation of 5-methylcytosine (5mC) and produce and safeguard …

Multi-cellular organisms such as humans contain hundreds of cell types that share the same
genetic information (DNA sequences), and yet have different cellular traits and functions …

Chronic diseases account for over 60% of all deaths worldwide according to the World
Health Organization reports. Majority of cases are triggered by environmental exposures that …

One of the most systematically studied bioactive nutraceuticals for its benefits in the
management of various diseases is the turmeric-derived compounds: curcumin. Turmeric …

Methylation of the fifth position of cytosine (5mC) is an important epigenetic modification of
DNA. It has been shown that the oxidized derivatives of 5mC, namely 5 …

DNA methylation is one of the main epigenetic mechanisms in cancer development and
progression. Aberrant DNA methylation of CpG islands within promoter regions contributes …

DNA methylation occurs primarily at cytosine in cytosine-guanine dinucleotides (CpG) and
involves the addition of a methyl group to carbon number 5 in cytosine to form 5 …

DNA methylation is known as the prima donna epigenetic mark for its critical role in
regulating local gene transcription. Changes in the landscape of DNA methylation across …

TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene
expression. Dysregulation of their activity is associated with many serious pathogenic states …

DNA methylation is one among the major grounds of cancer progression which is
characterized by the addition of a methyl group to the promoter region of the gene thereby …