Exercise is fundamental for good health, whereas physical inactivity underpins many chronic
diseases of modern society. It is well appreciated that regular exercise improves metabolism …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional
states throughout organism development. Epigenetics modifications, such as DNA …

DNA methylation is a key layer of epigenetic regulation. The deposition of methylation marks
relies on the catalytic activity of DNA methyltransferases (DNMTs), and their active removal …

Epigenetic remodeling is essential for oncogene-induced cellular transformation and
malignancy. In contrast to histone post-translational modifications, how DNA methylation is …

The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …

Fumarate hydratase (FH) is an enzyme of the Tricarboxylic Acid (TCA) cycle whose
mutations lead to hereditary and sporadic forms of cancer. Although more than twenty years …

R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function
isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2 …

Determining causal relationships between distinct chromatin features and gene expression,
and ultimately cell behavior, remains a major challenge. Recent developments in targetable …

Since the first identification of hypoxic cells in sections of carcinomas in the 1950s, hypoxia
has been known as a central hallmark of cancer cells and their microenvironment. Indeed …