QSER1 protects DNA methylation valleys from de novo methylation
INTRODUCTION DNA methylation is essential to mammalian development, and
dysregulation can cause serious pathological conditions, including immunodeficiency …
dysregulation can cause serious pathological conditions, including immunodeficiency …
[HTML][HTML] Targeting CDK9 reactivates epigenetically silenced genes in cancer
Summary Cyclin-dependent kinase 9 (CDK9) promotes transcriptional elongation through
RNAPII pause release. We now report that CDK9 is also essential for maintaining gene …
RNAPII pause release. We now report that CDK9 is also essential for maintaining gene …
[HTML][HTML] TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
[HTML][HTML] Intrauterine programming of obesity and type 2 diabetes
The type 2 diabetes epidemic and one of its predisposing factors, obesity, are major
influences on global health and economic burden. It is accepted that genetics and the …
influences on global health and economic burden. It is accepted that genetics and the …
The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system
T Kietzmann, A Petry, A Shvetsova… - British journal of …, 2017 - Wiley Online Library
Cardiovascular diseases are among the leading causes of death worldwide. Reactive
oxygen species (ROS) can act as damaging molecules but also represent central hubs in …
oxygen species (ROS) can act as damaging molecules but also represent central hubs in …
Dynamics and context-dependent roles of DNA methylation
C Ambrosi, M Manzo, T Baubec - Journal of molecular biology, 2017 - Elsevier
DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …
transcriptional gene silencing and plays important roles during mammalian development. Its …
TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures
Enzymes of the TET family are methylcytosine dioxygenases that undergo frequent
mutational or functional inactivation in human cancers. Recurrent loss-of-function mutations …
mutational or functional inactivation in human cancers. Recurrent loss-of-function mutations …
[图书][B] Medicinal chemistry of anticancer drugs
C Avendaño, JC Menéndez - 2015 - books.google.com
Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment
from the point of view of medicinal chemistry and drug design, focusing on the mechanism of …
from the point of view of medicinal chemistry and drug design, focusing on the mechanism of …
Undercover: gene control by metabolites and metabolic enzymes
JA van der Knaap, CP Verrijzer - Genes & development, 2016 - genesdev.cshlp.org
To make the appropriate developmental decisions or maintain homeostasis, cells and
organisms must coordinate the expression of their genome and metabolic state. However …
organisms must coordinate the expression of their genome and metabolic state. However …
TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells
Abstract TET enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC),
which can lead to DNA demethylation. However, direct connections between TET-mediated …
which can lead to DNA demethylation. However, direct connections between TET-mediated …