Background High expression of immune checkpoints in tumor microenvironment plays
significant roles in inhibiting anti-tumor immunity, which is associated with poor prognosis …

Simple Summary Aberrant DNA methylation is associated with multiple malignancies,
including lung cancer. Differences in methylation patterns have been observed across lung …

Mammalian hair cells do not functionally regenerate in adulthood but can regenerate at
embryonic and neonatal stages in mice by direct transdifferentiation of neighboring …

The biological function of PRMT5 remains poorly understood in cervical cancer metastasis.
Here, we report that PRMT5 physically associates with the transcription factor Snail and the …

The aim of the present review paper is to survey the literature related to DNA methylation,
and its association with cancer and ageing. The review will outline the key factors, including …

Mutations of ASXL1, encoding a component of the BAP1 histone H2A deubiquitinase
complex, occur in human myeloid neoplasms and are uniformly associated with poor …

The development of metastatic cancer is a multistage process, which often requires decades
to complete. Impairments in DNA damage control and DNA repair in cancer cell precursors …

BACKGROUND Infertility and pregnancy loss are longstanding problems. Successful
fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies …

Epstein–Barr virus-associated diseases are important global health concerns. As a group I
carcinogen, EBV accounts for 1.5% of human malignances, including both epithelial-and …

DNA methylation is a vital modification process in the control of genetic information, which
contributes to the epigenetics by regulating gene expression without changing the DNA …