Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …

Human brain organoids represent remarkable platforms for recapitulating features of human
brain development and diseases. Existing organoid models do not resolve fine brain …

The cerebral cortex is at the core of brain functions that are thought to be particularly
developed in the human species. Human cortex specificities stem from divergent features of …

Dysregulation of alternative splicing has been repeatedly associated with
neurodevelopmental disorders, but the extent of cell-type-specific splicing in human neural …

Tremendous progress has been made in the field of toxicology leading to the advance of
developmental toxicity assessment. Conventional animal models and in vitro two …

A drastic transition at birth, from constant maternal nutrient supply in utero to intermittent
postnatal feeding, requires changes in the metabolic system of the neonate. Despite their …

The endocannabinoid system (ECS) is a highly versatile signaling system within the nervous
system. Despite its widespread localization, its functions within the context of distinct neural …

Scientists have been fascinated by the human brain for centuries, yet knowledge of the
cellular and molecular events that build the human brain during embryogenesis and of how …