DNA methylation, ie, addition of methyl group to 5′-carbon of cytosine residues in CpG
dinucleotides, is an important epigenetic modification regulating gene expression, and thus …

Methylation of CpG dinucleotides plays a crucial role in the regulation of gene expression
and therefore in the development of different pathologies. Aberrant methylation has been …

Epigenetic mechanisms are moving to the forefront of environmental sciences, as
environmentally induced epigenetic changes shape biological responses to chemical …

Background: Gastric cancer (GC) is one of the most common malignancies, with a low 5-
year survival rate. However, if diagnosed at an early stage, it can be cured by endoscopic …

Background Hypertrophy of ligamentum flavum (HLF) is a common lumbar degeneration
disease (LDD) with typical symptoms of low back pain and limb numbness owing to an …

Hypoxia is involved in the epigenetic modification of leukemia. As an important DNA
hydroxymethylase and a tumor suppressor gene, the expression regulating mechanism of …

Histone deacetylases (HDACs), especially HDAC2, play a role in alleviating liver fibrosis;
however, the specific upstream regulation mechanism is unknown. Herein, TargetScan was …

Background/Aim: Intraductal papillary neoplasms of the bile duct (IPNB) are histologically
and clinically classified as type 1 and 2. This study aimed to identify the differences between …

Metastatic progression is a complex, multistep process and the leading cause of cancer
mortality. There is growing evidence that emphasises the significance of epigenetic …

Background Esophageal cancer (EC) is a prevalent malignancy characterized by a low 5-
year survival rate, primarily attributed to delayed diagnosis and limited therapeutic options …