Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

Highlights•Mutant K13-mediated artemisinin resistance involves reduced hemoglobin
endocytosis.•Artemisinin partial resistance has emerged in Africa.•Novel PfCRT mutations …

Background CIS43LS is a monoclonal antibody that was shown to protect against controlled
Plasmodium falciparum infection in a phase 1 clinical trial. Whether a monoclonal antibody …

Drug-resistant Plasmodium falciparum parasites have swept across Southeast Asia and now
threaten Africa. By implementing a P. falciparum genetic cross using humanized mice, we …

Mozambique is one of the four African countries which account for over half of all malaria
deaths worldwide, yet little is known about the parasite genetic structure in that country. We …

Page 1 UN WATER World Health Organization STRONG SYSTEMS AND SOUND
INVESTMENTS EVIDENCE ON AND KEY INSIGHTS INTO ACCELERATING PROGRESS ON …

Malaria remains one of the most important infectious diseases in the world, with the greatest
burden in sub-Saharan Africa, primarily from Plasmodium falciparum infection. The …

Background Cabamiquine is a novel antimalarial that inhibits Plasmodium falciparum
translation elongation factor 2. We investigated the causal chemoprophylactic activity and …

Fluorescence and light microscopy are important tools in the history of natural science.
However, the resolution of microscopes is limited by the diffraction of light. One possible …

Abstract Background Artesunate–amodiaquine (AS–AQ) and artemether–lumefantrine (AL)
are the currently recommended first-and second-line therapies for uncomplicated …