Abstract Ketamine (Ket) and midazolam (Mdz) are among well-known anesthetic agents
which frequently coadministered in surgical procedures and emergency department. Only a …

In the evolving field of drug discovery and development, multiorgans-on-a-chip and
microphysiological systems are gaining popularity owing to their ability to emulate in vivo …

For the quantification of the sedative and anesthetic drug midazolam and its main (active)
metabolites 1-hydroxymidazolam, 4-hydroxymidazolam and 1-hydroxymidazolam …

Objectives: To develop a pharmacokinetic-pharmacogenomic population model of
midazolam in critically ill children with primary respiratory failure. Design: Prospective …

Ketamine (Ket) and midazolam (MDZ) are commonly administered drugs in the intensive
care setting for analgesia and sedation. Ket and MDZ are metabolized to dehydro …

A sensitive and selective high-performance liquid chromatographic method coupled to
tandem mass spectrometry was developed and validated for the quantification of morphine …

Sedative use can result in adverse drug reactions. Intensive care unit patients are especially
at risk and pharmacokinetic modeling of drug concentrations is an approach to develop …

Objective: To develop a pharmacokinetic-pharmacogenomic population model of morphine
in critically ill children with acute respiratory failure. Design: Prospective pharmacokinetic …

Objectives Refractory status epilepticus (RSE) is often treated with midazolam boluses and
continuous infusions, but there is considerable variability in dosing and efficacy. We aimed …

Background Vitamin D3 (VD3) is a commonly used supplement in clinical practice.
Cytochrome P450 3A11 (CYP3A11) is the most important monomeric enzyme involved in …