Shear stress and aneurysms: a review

B Staarmann, M Smith, CJ Prestigiacomo - Neurosurgical focus, 2019 - thejns.org
Wall shear stress, the frictional force of blood flow tangential to an artery lumen, has been
demonstrated in multiple studies to influence aneurysm formation and risk of rupture. In this …

Preclinical intracranial aneurysm models: a systematic review

F Strange, BE Grüter, J Fandino, S Marbacher - Brain sciences, 2020 - mdpi.com
Intracranial aneurysms (IA) are characterized by weakened cerebral vessel walls that may
lead to rupture and subarachnoid hemorrhage. The mechanisms behind their formation and …

Prostaglandin E2–EP2–NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms

T Aoki, J Frȍsen, M Fukuda, K Bando, G Shioi… - Science …, 2017 - science.org
Intracranial aneurysms are common but are generally untreated, and their rupture can lead
to subarachnoid hemorrhage. Because of the poor prognosis associated with subarachnoid …

Fluid–structure interaction (FSI) simulation for studying the impact of atherosclerosis on hemodynamics, arterial tissue remodeling, and initiation risk of intracranial …

AA Rostam-Alilou, HR Jarrah, A Zolfagharian… - … and modeling in …, 2022 - Springer
The biomechanical and hemodynamic effects of atherosclerosis on the initiation of
intracranial aneurysms (IA) are not yet clearly discovered. Also, studies for the observation of …

[HTML][HTML] New pathophysiological considerations on cerebral aneurysms

KH Jung - Neurointervention, 2018 - synapse.koreamed.org
Cerebral aneurysm is a common cerebrovascular disease that is sometimes complicated by
rupture or an enlarged mass. We are now aggressively evaluating and managing …

Roles of inflammation in the natural history of intracranial saccular aneurysms

J Wang, L Wei, H Lu, Y Zhu - Journal of the Neurological Sciences, 2021 - Elsevier
Aneurysmal subarachnoid hemorrhage is caused by intracranial aneurysm (IA) rupture and
results in high rates of mortality and morbidity. Factors contributing to IA generation, growth …

Vasa vasorum formation is associated with rupture of intracranial aneurysms

H Miyata, H Imai, H Koseki, K Shimizu, Y Abekura… - Journal of …, 2019 - thejns.org
OBJECTIVE Subarachnoid hemorrhage (SAH) has a poor outcome despite modern
advancements in medical care. The development of a novel therapeutic strategy to prevent …

A sphingosine‐1‐phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage …

R Yamamoto, T Aoki, H Koseki… - British journal of …, 2017 - Wiley Online Library
Background and Purpose Intracranial aneurysm (IA), common in the general public, causes
lethal subarachnoid haemorrhage on rupture. It is, therefore, of utmost importance to prevent …

T cell function is dispensable for intracranial aneurysm formation and progression

H Miyata, H Koseki, K Takizawa, H Kasuya, K Nozaki… - PloS one, 2017 - journals.plos.org
Given the social importance of intracranial aneurysm as a major cause of a lethal
subarachnoid hemorrhage, clarification of mechanisms underlying the pathogenesis of this …

The vascular protective role of oestradiol: a focus on postmenopausal oestradiol deficiency and aneurysmal subarachnoid haemorrhage

SS Ramesh, R Christopher, B Indira Devi… - Biological …, 2019 - Wiley Online Library
The steroid hormone, oestradiol, has pleiotropic functions. The protective effects of
oestradiol are attributed to its anti‐inflammatory, antioxidant, anti‐atherogenic, anti …