Simple Summary Aberrant DNA methylation is associated with multiple malignancies,
including lung cancer. Differences in methylation patterns have been observed across lung …

Simple Summary Multifactorial diseases are caused by a combination of genetic and
environmental factors and various risk factors that accumulate with age. Cardiovascular …

Small cell lung cancer (SCLC) is an aggressive malignancy composed of distinct
transcriptional subtypes, but implementing subtyping in the clinic has remained challenging …

The intestinal microbiome releases a plethora of small molecules. Here, we show that the
Ruminococcaceae metabolite isoamylamine (IAA) is enriched in aged mice and elderly …

The mechanism by which anti-cancer immunity shapes early carcinogenesis of lung
adenocarcinoma (ADC) is unknown. In this study, we characterize the immune contexture of …

Rationale: Ground-glass opacity (GGO)-associated lung cancers are common and
radiologically distinct clinical entities known to have an indolent clinical course and superior …

Recent statistics on lung cancer, including the steady decline of advanced diseases and the
dramatically increasing detection of early-stage diseases and indeterminate pulmonary …

Cell-free DNA (cfDNA) sequencing has demonstrated great potential for early cancer
detection. However, most large-scale studies have focused only on either targeted …

Background Immune checkpoint inhibition therapy has been achieved significant success in
the treatment of non-small cell lung cancer (NSCLC). However, the role of soluble immune …

The mechanism underlying the development of tumors, particularly at early stages, still
remains mostly elusive. Here, we report whole-genome long and short read sequencing …