Irinotecan (CPT11) and its active metabolite ethyl-10-hydroxy-camptothecin (SN38) are
broad-spectrum cytotoxic anticancer agents. Both cause cell death in rapidly dividing cells …

Monoclonal antibody inhibitors of the epidermal growth factor receptor (EGFR) have been
shown to improve outcomes for patients with metastatic colorectal cancer (mCRC) without …

The clinical success of nanomedicines demands on the development of simple
biodegradable nanocarriers that can efficiently and stably encapsulate chemotherapeutics …

Autophagy is an evolutionarily conserved stress response mechanism that often occurs in
apoptosis-defective cancer cells and can protect against cell death. In this study, we …

Objectives Chemotherapy-induced peripheral neuropathy is frequently a dose-limiting factor
in cancer treatment and may cause pain and irreversible function loss in cancer survivors …

The clinical relevance of circadian rhythm modifications in patients on chemotherapy is
unknown. Even so, circadian parameter I< O before chemotherapy independently predicted …

Colorectal cancer (CRC) is the third most common cancer worldwide and is associated with
a poor clinical outcome and survival. Therefore, the development of novel therapeutic …

Vascular endothelial growth factor (VEGF) targeted therapy, either alone or in combination
with chemotherapy, has become the standard of care in several solid tumours, including …

Maslinic acid (MA) is a pentacyclic triterpene acid, which exists in many plants, including
olive, and is highly safe for human beings. In recent years, it has been reported that MA has …

Betulinic acid (BetA) is a plant-derived pentacyclic triterpenoid with potent anticancer
capacity that targets the mitochondrial pathway of apoptosis. BetA has a broad efficacy in …