Sex differences between women and men are often overlooked and underappreciated when
studying the cardiovascular system. It has been long assumed that men and women are …

Many mouse models of abdominal aortic aneurysms have been developed that use a
diverse array of methods for producing the disease, including genetic manipulation and …

Objective—We sought to define the temporal characteristics of angiotensin II (AngII)-induced
abdominal aortic aneurysms (AAAs) and to provide mechanistic insight into the development …

Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix
(ECM) fragmentation and inflammation. However, the mechanisms by which these events …

Objective—Obesity promotes macrophage infiltration into adipose tissue and is associated
with increases in several cardiovascular diseases. Infusion of angiotensin II (AngII) to mice …

Objective—Angiotensin II (AngII) infusion into hyperlipidemic mice leads to the rapid
formation of atherosclerotic lesions and abdominal aortic aneurysms (AAAs). To define the …

Abstract Activation of the 5-lipoxygenase (5-LO) pathway leads to the biosynthesis of
proinflammatory leukotriene lipid mediators. Genetic studies have associated 5-LO and its …

Aortic diseases comprise aneurysms, dissections, and several other pathologies. In general,
aging is associated with a slow but progressive dilation of the aorta, along with increased …

Objective The purpose of this study was to establish a reliable, chronic model of abdominal
aortic aneurysm (AAA). Methods Wild-type 8-week-old C56BL/6 male mice (n= 120) were …

Angiotensin II (AngII) infusion initiates abdominal aortic aneurysm (AAA) development due
to medial disruption and results in luminal dilation and thrombus formation. The objective of …