Cell cycle regulation is orchestrated by a complex network of interactions between proteins,
enzymes, cytokines, and cell cycle signaling pathways, and is vital for cell proliferation …

Since it was first recognized in bacteria and archaea as a mechanism for innate viral
immunity in the early 2010s, clustered regularly interspaced short palindromic repeats …

DNA methylation is an important epigenetic modification involved in gene regulation and
transposable element silencing. Changes in DNA methylation can be heritable and, thus …

DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …

Background Cytosine methylation is crucial for gene regulation and silencing of
transposable elements in mammals and plants. While this epigenetic mark is extensively …

As one of the bicyclic metabolic pathways of one-carbon metabolism, methionine
metabolism is the pivot linking the folate cycle to the transsulfuration pathway. In addition to …

Two waves of DNA methylation reprogramming occur during mammalian embryogenesis;
during preimplantation development and during primordial germ cell (PGC) formation …

Background Cellular compositions of solid tumor microenvironments are heterogeneous,
varying across patients and tumor types. High-resolution profiling of the tumor …

The ability of a cell to dynamically switch its chromatin between different functional states
constitutes a key mechanism regulating gene expression. Histone mark “readers” display …

Abstract Background In Alzheimer's Disease (AD), about one-third of the risk genes
identified by GWAS encode proteins that function predominantly in the endocytic pathways …