Background Energy balance has long been known to extend lifespans and inhibit
carcinogenesis in multiple species by slowing age‐related epigenetic changes while the …

Following implantation, the naive pluripotent epiblast of the mouse blastocyst generates a
rosette, undergoes lumenogenesis and forms the primed pluripotent egg cylinder, which is …

Myocardial fibrosis (MF) is a reactive remodeling process in response to myocardial injury. It
is mainly manifested by the proliferation of cardiac muscle fibroblasts and secreting …

Abstract Background In Alzheimer's Disease (AD), about one-third of the risk genes
identified by GWAS encode proteins that function predominantly in the endocytic pathways …

Adverse childhood experiences (ACEs), or cumulative childhood stress exposures, such as
abuse, neglect, and household dysfunction, predict later health problems in both the …

Introduction The human brain comprises heterogeneous cell types whose composition can
be altered with physiological and pathological conditions. New approaches to discern the …

DNA methylation is an essential epigenetic modification for mammalian embryonic
development and biology. The DNA methylation pattern across the genome, together with …

Depression is one of the most common mental diseases, with increasing numbers of
patients globally each year. In addition, approximately 30% of patients with depression are …

Precision in the establishment and maintenance of cellular identities is crucial for the
development of multicellular organisms and requires tight regulation of gene expression …

Aging is a significant risk factor for various human disorders, and DNA methylation clocks
have emerged as powerful tools for estimating biological age and predicting health‐related …