Background High-throughput technologies enable the cost-effective collection and analysis
of DNA methylation data throughout the human genome. This naturally entails missing …

Pluripotent and post‐natal, tissue‐specific stem cells share functional features such as the
capacity to differentiate into multiple lineages and to self‐renew, and are endowed with …

Inflammation is the body's means of defense against harmful stimuli, with the ultimate aim
being to restore homeostasis. Controlled acute inflammation transiently activates an immune …

Background Depicting the heterogeneity and functional characteristics of the tumor
microenvironment (TME) is necessary to achieve precision medicine for bladder cancer …

Pulmonary arterial hypertension (PAH) is a devastating vascular disease with multiple
etiologies. Emerging evidence supports a fundamental role for epigenetic machinery and …

From the onset of fertilization, the genome undergoes cell division and differentiation. All of
these developmental transitions and differentiation processes include cell-specific …

Progesterone synthesized in the placenta is essential for pregnancy maintenance.
CYP11A1 is a key enzyme in progesterone synthesis, and its expression increases greatly …

Thyroid hormone (T3) plays pivotal roles in vertebrate development, acting via nuclear T3
receptors (TRs) that regulate gene transcription by promoting post-translational …

Abstract Paclitaxel (PTX), a tubulin-binding agent, is widely used and has shown good
efficacy in the initial period of treatment for non-small cell lung cancer (NSCLC). However …

N6‐methyladenosine (m6A) modification is the most prevalent chemical modification in
eukaryotic mRNA and is associated with the development of various immune diseases …