Among the 28 identified and unique mammalian TRP (transient receptor potential) channel
isoforms, at least 19 are expressed in vascular endothelial cells. These channels appear to …

Molecular pathogenesis of ADPKD: The polycystin complex gets complex. Autosomal-
dominant polycystic kidney disease (ADPKD) is one of the most common human monogenic …

Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize
to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw …

Polycystin-2, the product of the gene mutated in type 2 autosomal dominant polycystic
kidney disease (ADPKD), is the prototypical member of a subfamily of the transient receptor …

Defects in polycystin-2, a ubiquitous transmembrane glycoprotein of unknown function, is a
major cause of autosomal dominant polycystic kidney disease (ADPKD), whose …

Cardiovascular complications such as hypertension are a continuous concern in patients
with autosomal dominant polycystic kidney disease (ADPKD). The PKD2 encoding for …

Mutations in cystic kidney disease genes represent a major genetic cause of end‐stage
renal disease. However, the molecular cascades controlling the expression of these genes …

Cilia are small microtubule‐based cellular appendages that are broadly classified as being
either motile or immotile (primary cilia). Since their initial discovery several centuries ago …

Consider a hypothetical design specification for an integrated communication-control system
within an embryo. It would require short-range (subcellular) and long-range (pan-embryonic) …

Autosomal dominant polycystic kidney disease (ADPKD) is common and is a major cause of
renal failure. Although the genetics of ADPKD are well known and have led to the discovery …