[HTML][HTML] ZAP-70 shapes the immune microenvironment in B cell malignancies
J Chen, A Moore, I Ringshausen - Frontiers in Oncology, 2020 - frontiersin.org
Zeta-chain-associated protein kinase-70 (ZAP-70) is a tyrosine kinase mainly expressed in T
cells, NK cells and a subset of B cells. Primarily it functions in T cell receptor (TCR) activation …
cells, NK cells and a subset of B cells. Primarily it functions in T cell receptor (TCR) activation …
[HTML][HTML] The immunomodulatory effect of koumine on B cells under dependent and independent responses by T cells
Y Lin, Q Liu, Z Chen, F Zheng, H Huang, C Yu… - European Journal of …, 2022 - Elsevier
Dysregulated activation of polyclonal B cells and production of pathogenic antibodies are
involved in the development of rheumatoid arthritis (RA). Therefore, targeted B cell therapy …
involved in the development of rheumatoid arthritis (RA). Therefore, targeted B cell therapy …
Role of Wiskott Aldrich syndrome protein in haematological malignancies: genetics, molecular mechanisms and therapeutic strategies
R Pradeep, G Shanmugam, S Rakshit… - Pathology-Research and …, 2023 - Elsevier
As patients continue to suffer from lymphoproliferative and myeloproliferative diseases
known as haematopoietic malignancies can affect the bone marrow, blood, lymph nodes …
known as haematopoietic malignancies can affect the bone marrow, blood, lymph nodes …
[HTML][HTML] CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression
C Rodrigues, P Laranjeira, A Pinho, I Silva… - Frontiers in …, 2024 - frontiersin.org
Introduction In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia
(CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions …
(CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions …
[HTML][HTML] Morniga-G, a T/Tn-specific lectin, induces leukemic cell death via caspase and DR5 receptor-dependent pathways
G Poiroux, A Barre, M Simplicien, S Pelofy… - International Journal of …, 2019 - mdpi.com
Morniga-G, the Gal-specific black mulberry (Morus nigra) lectin, displays high affinity for T
(CD176) and Tn (CD175) antigens, frequently expressed at the cancer cell surface. The …
(CD176) and Tn (CD175) antigens, frequently expressed at the cancer cell surface. The …
The presence of CpGs in AAV gene therapy vectors induces a plasmacytoid dendritic cell-like population very early after administration
JD Glenn, H Negash, W Henry, R Qian, Y Liu… - Cellular …, 2024 - Elsevier
AAV-mediated gene transfer is a promising platform still plagued by potential host-derived,
antagonistic immune responses to therapeutic components. CpG-mediated TLR9 …
antagonistic immune responses to therapeutic components. CpG-mediated TLR9 …
[HTML][HTML] Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies
G Biber, A Ben-Shmuel, E Noy, N Joseph… - Nature …, 2021 - nature.com
Cancer cells depend on actin cytoskeleton rearrangement to carry out hallmark malignant
functions including activation, proliferation, migration and invasiveness. Wiskott–Aldrich …
functions including activation, proliferation, migration and invasiveness. Wiskott–Aldrich …
[HTML][HTML] Evaluation of immunophenotypic markers and clinico-hematological profile in chronic lymphocytic leukemia: implications for prognosis
Objective Chronic lymphocytic leukemia (CLL) is an adult leukemia presented with clonal
accumulation of lymphocytes. Immunophenotypic changes can be effective in predicting …
accumulation of lymphocytes. Immunophenotypic changes can be effective in predicting …
Intensity of antigen expression reflects IGHV mutational status and Dohner-defined prognostic categories in chronic lymphocytic leukemia, monoclonal B-cell …
J Balakrishna, N Basumallik, R Matulonis… - Leukemia & …, 2021 - Taylor & Francis
We demonstrate the prognostic utility of antigen quantitation in chronic lymphocytic
leukemia/small lymphocytic lymphoma (CLL/SLL) and monoclonal B-cell lymphocytosis …
leukemia/small lymphocytic lymphoma (CLL/SLL) and monoclonal B-cell lymphocytosis …
Prognostic Relevance of CD69, Vascular Endothelial Growth Factor and Thymidine Kinase in B-Chronic Lymphocytic Leukemia
RI Noreldin, RS El Zaiat, IA Ahmedy - The Egyptian Journal of …, 2023 - journals.ekb.eg
Background: B-chronic-lymphocytic-leukemia (B-CLL) is a heterogeneous illness with a
varied clinical history. Some individuals don't require therapy while others have an …
varied clinical history. Some individuals don't require therapy while others have an …