Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak
emerged, countless efforts are being made worldwide to understand the molecular …

Background Melatonin is an indole hormone secreted primarily by the pineal gland that
showing anti-oxidant, anti-inflammatory and anti-apoptotic capacity. It can play an important …

Combined chemotherapy is a treatment method based on the simultaneous use of two or
more therapeutic agents; it is frequently necessary to produce a more effective treatment for …

Melatonin is a ubiquitous hormone found in various organisms and highly affects the
function of immune cells. In this review, we summarize the current understanding of the …

Fluorouracil (5‐FU) is one of the most commonly used chemotherapeutic agents in colon
cancer treatment, but has a narrow therapeutic index limited by its toxicity. Melatonin exerts …

An association of melatonin levels with age disease initiation of autoimmune diseases and
pineal calcification was reported while an inverse association between melatonin levels and …

Whether the retinoic acid-related orphan receptor (ROR) is a nuclear receptor of melatonin
remains controversial. ROR is inextricably linked to melatonin in terms of its expression …

Melatonin is an indolamine synthesized and secreted by the pineal gland along with other
extrapineal sources including immune system cells, the brain, skin and the gastrointestinal …

Multiple sclerosis (MS) is a chronic inflammatory disease, which leads to focal plaques of
demyelination and tissue injury in the central nervous system (CNS). Neuroinflammation …

Bone marrow mesenchymal stem cells (BMSC s) are an expandable population of stem
cells which can differentiate into osteoblasts, chondrocytes and adipocytes. Dysfunction of …